META-ANALYSIS OF INCIDENCE OF BRAIN CANCER AMONG AIRCREW

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LIU TIEBING; ZHANG CHANYUAN; WANG SHANSHAN; ZHANG JIN

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Journal: International Journal of Travel Medicine and Global Health Year:2017 | Volume:5 | Issue:1 Page(s): 14-19

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Title

META-ANALYSIS OF INCIDENCE OF BRAIN CANCER AMONG AIRCREW

Author(s)

LIU TIEBING | ZHANG CHANYUAN | WANG SHANSHAN | ZHANG JIN | Issue Writer Certificate

Keywords

BRAIN NEOPLASMS

NERVOUS SYSTEM NEOPLASMS

AIRCREW

META-ANALYSIS

Abstract

Introduction: Previous studies on brain and other nervous system cancers (BNSC) and AIRCREW have shown inconsistent results, possibly due to their relatively small sample sizes; therefore, the current study aimed to increase the precision of risk estimates.Methods: Systematic searches of PubMed and Embase for pertinent studies up to August 2016 were performed and supplemented by manual reviews of bibliographies. The pooled standard incidence ratio (SIR) and corresponding 95% CIs were estimated with random effects models.Results: Among the 903 studies retrieved, 7 studies (5 cohort studies and 2 pooled analyses) were included in the current META-ANALYSIS. The pooled SIR (95% CI) of BNSC incidence in AIRCREW was 1.01 (0.77, 1.31) with no significant heterogeneity (I2=36.1%, P=.199). The null association persisted when the analysis was stratified by geographic area (Europe or America), publication year (before or after 2001), air population (pilots or cabin crew), cancer site (brain, nervous system, or brain/nervous system), and gender (male or female).Conclusion: The current evidence is not sufficient to support a significant positive association between AIRCREW employment and BNSC risk. However, the interpretation and extrapolation of this META-ANALYSIS are restricted by the possible impact exerted by health worker effect and potential clinical heterogeneity. More studies based on other populations, including Asian AIRCREWs, are warranted.

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APA: Copy

LIU, TIEBING, ZHANG, CHANYUAN, WANG, SHANSHAN, & ZHANG, JIN. (2017). META-ANALYSIS OF INCIDENCE OF BRAIN CANCER AMONG AIRCREW. INTERNATIONAL JOURNAL OF TRAVEL MEDICINE AND GLOBAL HEALTH, 5(1), 14-19. SID. https://sid.ir/paper/350422/en

Vancouver: Copy

LIU TIEBING, ZHANG CHANYUAN, WANG SHANSHAN, ZHANG JIN. META-ANALYSIS OF INCIDENCE OF BRAIN CANCER AMONG AIRCREW. INTERNATIONAL JOURNAL OF TRAVEL MEDICINE AND GLOBAL HEALTH[Internet]. 2017;5(1):14-19. Available from: https://sid.ir/paper/350422/en

IEEE: Copy

TIEBING LIU, CHANYUAN ZHANG, SHANSHAN WANG, and JIN ZHANG, “META-ANALYSIS OF INCIDENCE OF BRAIN CANCER AMONG AIRCREW,” INTERNATIONAL JOURNAL OF TRAVEL MEDICINE AND GLOBAL HEALTH, vol. 5, no. 1, pp. 14–19, 2017, [Online]. Available: https://sid.ir/paper/350422/en

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