مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

STATUS OF TOTAL ANTIOXIDANT CAPACITY AND MALONDIALDEHYDE LEVEL IN METHAMPHETAMINE ADDICTS: A CROSS SECTIONAL STUDY

Pages

  19-25

Abstract

 Background: METHAMPHETAMINE (MA) is an illegal amphetamine-like which stimulate the central nervous system. In recent years, MA has been widely ABUSEd worldwide. Previous studies have suggested that OXIDATIVE STRESS (OS) plays an important role in MA-induced toxicity. From this view, ANTIOXIDANT therapy could be considered as a potential drug therapy in MA ABUSErs. Therefore, the objective of this study was to evaluate OS status in MA ABUSErs.Methods: This was a cross-sectional study conducted on 21 MA ABUSErs who referred to Iranian National Center for Addiction Studies and Congress 60 Humane Revivification Society, and 15 healthy males as a control group. The demographic data and peripheral blood sampling was obtained from both groups. The serum MALONDIALDEHYDE (MDA) level as a marker of plasma lipid peroxidation and total ANTIOXIDANT capacity (TAC) of plasma were analyzed.Results: Significant decrease in plasma TAC in case group was observed (101.85±12.5 vs.130.7±16.12 mmol/L). No significant increase in MDA serum level was detected in case group in comparison with control (27.35±2.6 vs.26.67±2.22 mmol/L, respectively). Neither the serum MDA levels nor the plasma TAC were significantly correlated with the duration and amount of MA ABUSE.Conclusion: It seems that, MA ABUSE is associated with prooxidant-antioxidant imbalance, which suggests evaluation the role of ANTIOXIDANTs administration for the prevention and treatment of MA-induced toxicity.

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    • Cite

    APA: Copy

    SHADNIA, S., GORGZADEH, N., SOLTANINEJAD, K., ABDOLLAHI, M., & MOTEVALIAN, S.A.. (2017). STATUS OF TOTAL ANTIOXIDANT CAPACITY AND MALONDIALDEHYDE LEVEL IN METHAMPHETAMINE ADDICTS: A CROSS SECTIONAL STUDY. INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE, 7(1), 19-25. SID. https://sid.ir/paper/350552/en

    Vancouver: Copy

    SHADNIA S., GORGZADEH N., SOLTANINEJAD K., ABDOLLAHI M., MOTEVALIAN S.A.. STATUS OF TOTAL ANTIOXIDANT CAPACITY AND MALONDIALDEHYDE LEVEL IN METHAMPHETAMINE ADDICTS: A CROSS SECTIONAL STUDY. INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE[Internet]. 2017;7(1):19-25. Available from: https://sid.ir/paper/350552/en

    IEEE: Copy

    S. SHADNIA, N. GORGZADEH, K. SOLTANINEJAD, M. ABDOLLAHI, and S.A. MOTEVALIAN, “STATUS OF TOTAL ANTIOXIDANT CAPACITY AND MALONDIALDEHYDE LEVEL IN METHAMPHETAMINE ADDICTS: A CROSS SECTIONAL STUDY,” INTERNATIONAL JOURNAL OF MEDICAL TOXICOLOGY AND FORENSIC MEDICINE, vol. 7, no. 1, pp. 19–25, 2017, [Online]. Available: https://sid.ir/paper/350552/en

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