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Information Journal Paper

Title

Modulatory Effect of Decalepis hamiltonii on Ethanol-Induced Neurotoxicity in Drosophila melanogaster

Pages

  63-71

Abstract

 Introduction: T Drosophila melanogaster is a suitable in vivo model organism to study the neurotoxic effects of Ethanol. In the present study, the behavioral responses, levels of oxidative markers, and activity of antioxidant enzymes were investigated in Ethanol-exposed Drosophila flies. Methods: Adult flies were exposed to absolute Ethanol using Ethanol exposure chamber. Then, their resistance against Ethanol vapor was measured by monitoring their locomotion. Biochemical assays were applied to quantify antioxidant enzymes activity in the brains of Ethanol exposed flies. Results: The results showed that acute Ethanol exposure led to the hyperactivity of flies. If alcohol exposure was prolonged, then sedation could occur in the experimental flies. The levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) as cellular markers of Oxidative stress considerably increased in Ethanol-exposed flies while glutathione (GSH) level declined. Higher activities of catalase (CAT) and superoxide dismutase (SOD) were observed in the Ethanol-exposed flies. Ethanol neurotoxicity became more evident when a remarkable decrease in acetylcholine esterase (AChE) activity was seen in the Ethanol-exposed flies. Treatment with Decalepis hamiltonii aqueous extract increased the time of ST50 and decreased the RC50 values of Ethanol-exposed flies. Moreover, we demonstrated that D. hamiltonii pre-treatment diminished ROS and LPO levels in the Ethanol-exposed flies. D. hamiltonii treatment resulted in augmentation of GSH level and activity of CAT and SOD enzymes. Conclusion: This is the first report on the protective effects of D. hamiltonii natural antioxidants in D. melanogaster on Oxidative stress induced by Ethanol.

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    APA: Copy

    Reiszadeh Jahromi, Samaneh. (2018). Modulatory Effect of Decalepis hamiltonii on Ethanol-Induced Neurotoxicity in Drosophila melanogaster. INTERNATIONAL JOURNAL OF BASIC SCIENCE IN MEDICINE, 3(2), 63-71. SID. https://sid.ir/paper/350709/en

    Vancouver: Copy

    Reiszadeh Jahromi Samaneh. Modulatory Effect of Decalepis hamiltonii on Ethanol-Induced Neurotoxicity in Drosophila melanogaster. INTERNATIONAL JOURNAL OF BASIC SCIENCE IN MEDICINE[Internet]. 2018;3(2):63-71. Available from: https://sid.ir/paper/350709/en

    IEEE: Copy

    Samaneh Reiszadeh Jahromi, “Modulatory Effect of Decalepis hamiltonii on Ethanol-Induced Neurotoxicity in Drosophila melanogaster,” INTERNATIONAL JOURNAL OF BASIC SCIENCE IN MEDICINE, vol. 3, no. 2, pp. 63–71, 2018, [Online]. Available: https://sid.ir/paper/350709/en

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