THALASSEMIA AN UPDATE: MOLECULAR BASIS, CLINICAL FEATURES AND TREATMENT

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Tari Kaveh; VALIZADEH ARDALAN POOYA; ABBASZADEHDIBAVAR MAHNOOSH; ATASHI AMIR; JALILI ALI; Gheidishahran Maryam

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Journal: INTERNATIONAL JOURNAL OF BIOMEDICINE AND PUBLIC HEALTH Year:2018 | Volume:1 | Issue:1 Page(s): 48-58

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Title

THALASSEMIA AN UPDATE: MOLECULAR BASIS, CLINICAL FEATURES AND TREATMENT

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Keywords

THALASSEMIA

MOLECULAR BASIS

CLINICAL FEATURES

TREATMENT

Abstract

THALASSEMIA are a group of inherited blood disorders caused by the decrease or absence of beta-globin chain synthesis will be determined with decrease in erythrocyte hemoglobin, decreased production of erythrocytes and anemia. More THALASSEMIA is inherited as recessive autosomal. According to this fact that which one of the chains are involved, they invide into two type including alpha and beta THALASSEMIA, which each of them including several types. THALASSEMIA major is more extensive and patient needs to blood transfusion, but THALASSEMIA minor is slight. The most important problem in this patient include iron overload, cardiac arrhythmia, hepatitis, osteoporosis and endocrine disorder however there are typical signs and symptoms of anemia. TREATMENT including Change of expression and production of HbF, Hematopoietic stem cell transplantation and Maintenance TREATMENT such as chelators therapy, Induction of fetal hemoglobin production by using Hydroxia urea, use of immunomodulator agents and Molecular Therapy by targeting of genes involving in HbF expression.in this article we review the THALASSEMIA disorder and discuss on MOLECULAR BASIS, CLINICAL FEATURES and TREATMENT.

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APA: Copy

Tari, Kaveh, VALIZADEH ARDALAN, POOYA, ABBASZADEHDIBAVAR, MAHNOOSH, ATASHI, AMIR, JALILI, ALI, & Gheidishahran, Maryam. (2018). THALASSEMIA AN UPDATE: MOLECULAR BASIS, CLINICAL FEATURES AND TREATMENT. INTERNATIONAL JOURNAL OF BIOMEDICINE AND PUBLIC HEALTH, 1(1), 48-58. SID. https://sid.ir/paper/350851/en

Vancouver: Copy

Tari Kaveh, VALIZADEH ARDALAN POOYA, ABBASZADEHDIBAVAR MAHNOOSH, ATASHI AMIR, JALILI ALI, Gheidishahran Maryam. THALASSEMIA AN UPDATE: MOLECULAR BASIS, CLINICAL FEATURES AND TREATMENT. INTERNATIONAL JOURNAL OF BIOMEDICINE AND PUBLIC HEALTH[Internet]. 2018;1(1):48-58. Available from: https://sid.ir/paper/350851/en

IEEE: Copy

Kaveh Tari, POOYA VALIZADEH ARDALAN, MAHNOOSH ABBASZADEHDIBAVAR, AMIR ATASHI, ALI JALILI, and Maryam Gheidishahran, “THALASSEMIA AN UPDATE: MOLECULAR BASIS, CLINICAL FEATURES AND TREATMENT,” INTERNATIONAL JOURNAL OF BIOMEDICINE AND PUBLIC HEALTH, vol. 1, no. 1, pp. 48–58, 2018, [Online]. Available: https://sid.ir/paper/350851/en

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