IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON CERVICAL AND COLORECTAL CANCER CELL LINES

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ABASTABAR M.; AKBARI A.; AKHTARI J.; HEDAYATI M.T.; SHOKOHI T.; MEHRAD MAJD H.; GHALEHNOEI H.; GHASEMI S.

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Journal Paper

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Journal: Current Medical Mycology Year:2017 | Volume:3 | Issue:1 Page(s): 25-29

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Title

IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON CERVICAL AND COLORECTAL CANCER CELL LINES

Author(s)

Keywords

CANCER

HELA CELLS

MYCOTOXIN

PATULIN

Abstract

Background and Purpose: PATULIN is a MYCOTOXIN produced by some molds, especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-CANCER potency of PATULIN, but some reports demonstrated that it induces cellular apoptosis and toxicity.Materials and Methods: To determine the efficacy of PATULIN as a therapeutic strategy for cervical and colorectal CANCERs, we investigated its effects on HeLa, SW-48, and MRC-5 cell lines. Cell lines were exposed to various concentrations of PATULIN (i.e., 0.5, 1, 2, and 4 μM), then using methyl thiazolyl tetrazolium (MTT) and bromo-2′-deoxyuridine (BrdU) assays, the rates of apoptosis and cell viability were determined.Results: The obtained results showed a significant reduction in cell viability and apoptosis induction in a dose-dependent manner. Among all the cell lines, the highest growth inhibition rate was obtained at the 4 μM concentration of PATULIN.Conclusion: Our results suggested that PATULIN could significantly decrease tumor growth in human cervical and colorectal CANCER models.

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APA: Copy

ABASTABAR, M., AKBARI, A., AKHTARI, J., HEDAYATI, M.T., SHOKOHI, T., MEHRAD MAJD, H., GHALEHNOEI, H., & GHASEMI, S.. (2017). IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON CERVICAL AND COLORECTAL CANCER CELL LINES. CURRENT MEDICAL MYCOLOGY, 3(1), 25-29. SID. https://sid.ir/paper/350883/en

Vancouver: Copy

ABASTABAR M., AKBARI A., AKHTARI J., HEDAYATI M.T., SHOKOHI T., MEHRAD MAJD H., GHALEHNOEI H., GHASEMI S.. IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON CERVICAL AND COLORECTAL CANCER CELL LINES. CURRENT MEDICAL MYCOLOGY[Internet]. 2017;3(1):25-29. Available from: https://sid.ir/paper/350883/en

IEEE: Copy

M. ABASTABAR, A. AKBARI, J. AKHTARI, M.T. HEDAYATI, T. SHOKOHI, H. MEHRAD MAJD, H. GHALEHNOEI, and S. GHASEMI, “IN VITRO ANTITUMOR ACTIVITY OF PATULIN ON CERVICAL AND COLORECTAL CANCER CELL LINES,” CURRENT MEDICAL MYCOLOGY, vol. 3, no. 1, pp. 25–29, 2017, [Online]. Available: https://sid.ir/paper/350883/en

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