EFFECT OF BIOGENIC SELENIUM NANOPARTICLES ON ERG11 AND CDR1 GENE EXPRESSION IN BOTH FLUCONAZOLE RESISTANT AND -SUSCEPTIBLE CANDIDA ALBICANS ISOLATES

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PARSAMEHER NASRIN; REZAEI SASAN; KHODAVAISY SADEGH; SALARI SAMIRA; HADIZADEH SANAZ; KORD MOHAMMAD; AYATOLLAHI MOUSAVI SEYYED AMIN

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Journal: Current Medical Mycology Year:2017 | Volume:3 | Issue:3 Page(s): 16-20

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Title

EFFECT OF BIOGENIC SELENIUM NANOPARTICLES ON ERG11 AND CDR1 GENE EXPRESSION IN BOTH FLUCONAZOLE RESISTANT AND -SUSCEPTIBLE CANDIDA ALBICANS ISOLATES

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Keywords

CANDIDA ALBICANS

CDR1

ERG 11

NANOPARTICLES

Abstract

Background and Purpose: CANDIDA ALBICANS is the most common Candida species (sp.) isolated from fungal infections. Azole resistance in Candida species has been considerably increased in the last decades. Given the toxicity of the antimicrobial drugs, resistance to antifungal agents, and drug interactions, the identification of new antifungal agents seems essential. In this study, we assessed the antifungal effects of biogenic selenium NANOPARTICLES on C. albicans and determined the expression of ERG11 and CDR1 genes.Materials and Methods: Selenium NANOPARTICLES were synthesized with Bacillus sp. MSH-1. The ultrastructure of selenium NANOPARTICLES was evaluated with a transmission electron microscope. The antifungal susceptibility test was performed according to the modified Clinical and Laboratory Standards Institute M27-A3 standard protocol. The expression levels of the CDR1 and ERG11 genes were analyzed using the quantitative real-time polymerase chain reaction (PCR) assay.Results: The azole-resistant C. albicans and wild type C. albicans strains were inhibited by 100 and 70 μg/mL of selenium nanoparticle concentrations, respectively. The expression of CDR1 and ERG11 genes was significantly down-regulated in these selenium nanoparticle concentrations.Conclusion: As the findings indicated, selenium NANOPARTICLES had an appropriate antifungal activity against fluconazole-resistant and -susceptible C. albicans strains. Accordingly, these NANOPARTICLES reduced the expression of CDR1 and ERG11 genes associated with azole resistance. Further studies are needed to investigate the synergistic effects of selenium NANOPARTICLES using other antifungal drugs.

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APA: Copy

PARSAMEHER, NASRIN, REZAEI, SASAN, KHODAVAISY, SADEGH, SALARI, SAMIRA, HADIZADEH, SANAZ, KORD, MOHAMMAD, & AYATOLLAHI MOUSAVI, SEYYED AMIN. (2017). EFFECT OF BIOGENIC SELENIUM NANOPARTICLES ON ERG11 AND CDR1 GENE EXPRESSION IN BOTH FLUCONAZOLE RESISTANT AND -SUSCEPTIBLE CANDIDA ALBICANS ISOLATES. CURRENT MEDICAL MYCOLOGY, 3(3), 16-20. SID. https://sid.ir/paper/350899/en

Vancouver: Copy

PARSAMEHER NASRIN, REZAEI SASAN, KHODAVAISY SADEGH, SALARI SAMIRA, HADIZADEH SANAZ, KORD MOHAMMAD, AYATOLLAHI MOUSAVI SEYYED AMIN. EFFECT OF BIOGENIC SELENIUM NANOPARTICLES ON ERG11 AND CDR1 GENE EXPRESSION IN BOTH FLUCONAZOLE RESISTANT AND -SUSCEPTIBLE CANDIDA ALBICANS ISOLATES. CURRENT MEDICAL MYCOLOGY[Internet]. 2017;3(3):16-20. Available from: https://sid.ir/paper/350899/en

IEEE: Copy

NASRIN PARSAMEHER, SASAN REZAEI, SADEGH KHODAVAISY, SAMIRA SALARI, SANAZ HADIZADEH, MOHAMMAD KORD, and SEYYED AMIN AYATOLLAHI MOUSAVI, “EFFECT OF BIOGENIC SELENIUM NANOPARTICLES ON ERG11 AND CDR1 GENE EXPRESSION IN BOTH FLUCONAZOLE RESISTANT AND -SUSCEPTIBLE CANDIDA ALBICANS ISOLATES,” CURRENT MEDICAL MYCOLOGY, vol. 3, no. 3, pp. 16–20, 2017, [Online]. Available: https://sid.ir/paper/350899/en

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