PREPARATION AND BIOLOGICAL ACTIVITY OF NEW COLLAGEN COMPOSITES, PART III. COLLAGEN/ (AG/ RGO) AND COLLAGEN/ (AG/ RGO/ SIO2) COMPOSITES

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VLADKOVA TODORKA G.; IVANOVA ILIANA A.; STANEVA ANNA D.; ALBU KAYA MADALINA G.; SHALABY AHMED S.A.; MOSKOVA DOUMANOVA VESELA; KOSTADINOVA ANELIA S.

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Journal: Journal of Archives in Military Medicine Year:2017 | Volume:5 | Issue:2 Page(s): 0-0

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Title

PREPARATION AND BIOLOGICAL ACTIVITY OF NEW COLLAGEN COMPOSITES, PART III. COLLAGEN/ (AG/ RGO) AND COLLAGEN/ (AG/ RGO/ SIO2) COMPOSITES

Author(s)

Keywords

COLLAGEN/(AG/RGO) AND COLLAGEN/(AG/RGO/SIO2) COMPOSITES

CYTOTOXICITY TO EUKARYOTIC CELLS: FIBROBLAST

OSTEOBLAST AND EPITHELIAL

ANTIMICROBIAL ACTIVITY: 3 GRAM-NEGATIVE (S. ENTERICA

P. AERUGINOSA AND E. COLI)

Abstract

The aim of this study is preparation, characterization, and biological activity evaluation of 2 new collagen composites, Collagen/ (Ag/ RGO) and Collagen/ (Ag/RGO/SiO2) with expected antimicrobial activity. The loading of collagen matrix by self-prepared Ag/RGO and Ag/RGO/SiO2 was varied. The morphology of these antimicrobial agents, as well as of the corresponding collagen composites, was observed by SEM. Their biological activity was evaluated against 3 Gram-negative and 3 Gram-positive microbial strains, as well as against 3 type eukaryotic cells: osteoblast, fibroblast, and epithelial. Dependent on the concentration of Ag/RGO, well pronounced activity against Gram-negative bacterium (E. coli), fungus (C. Lusistaniae) and 2 Gram-positive bacteria (S. epidermidis and B. cereus) was found for Collagen/ (Ag/RGO) composites at weight ratios of 2: 1, 2: 0.8, and 2: 0.6, at the last one accompanied by low cytotoxicity. Dependent on the concentration of Ag/RGO/SiO2 biological activity was found for the Collagen/ (Ag/RGO/SiO2) composites also, better expressed than that of Collagen/ (Ag/RGO) composites with the same level of antimicrobial agent loading. The experimental results demonstrated that the doping of RGO with Ag nanoparticles increases the antimicrobial activity of the Collagen/ (Ag/RGO) composites. Improving its dispersion, the silane matrix in the Ag/RGO/SiO2 additionally increases the biological activity of the studied Collagen/ (Ag/RGO/SiO2) composites and their well- pronounced, broad spectrum (against 3 Gram-negative, 2 Gram-positive bacteria and a fungus), antimicrobial activity is similar to that of the broad spectrum antibiotics. The novel Collagen/ (Ag/RGO) and Collagen/ (Ag/RGO/SiO2) composites are promising antimicrobial collagen biomaterials that widen the assortment of such for variety biomedical applications.

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APA: Copy

VLADKOVA, TODORKA G., IVANOVA, ILIANA A., STANEVA, ANNA D., ALBU KAYA, MADALINA G., SHALABY, AHMED S.A., MOSKOVA DOUMANOVA, VESELA, & KOSTADINOVA, ANELIA S.. (2017). PREPARATION AND BIOLOGICAL ACTIVITY OF NEW COLLAGEN COMPOSITES, PART III. COLLAGEN/ (AG/ RGO) AND COLLAGEN/ (AG/ RGO/ SIO₂) COMPOSITES. JOURNAL OF ARCHIVES IN MILITARY MEDICINE, 5(2), 0-0. SID. https://sid.ir/paper/350974/en

Vancouver: Copy

VLADKOVA TODORKA G., IVANOVA ILIANA A., STANEVA ANNA D., ALBU KAYA MADALINA G., SHALABY AHMED S.A., MOSKOVA DOUMANOVA VESELA, KOSTADINOVA ANELIA S.. PREPARATION AND BIOLOGICAL ACTIVITY OF NEW COLLAGEN COMPOSITES, PART III. COLLAGEN/ (AG/ RGO) AND COLLAGEN/ (AG/ RGO/ SIO₂) COMPOSITES. JOURNAL OF ARCHIVES IN MILITARY MEDICINE[Internet]. 2017;5(2):0-0. Available from: https://sid.ir/paper/350974/en

IEEE: Copy

TODORKA G. VLADKOVA, ILIANA A. IVANOVA, ANNA D. STANEVA, MADALINA G. ALBU KAYA, AHMED S.A. SHALABY, VESELA MOSKOVA DOUMANOVA, and ANELIA S. KOSTADINOVA, “PREPARATION AND BIOLOGICAL ACTIVITY OF NEW COLLAGEN COMPOSITES, PART III. COLLAGEN/ (AG/ RGO) AND COLLAGEN/ (AG/ RGO/ SIO₂) COMPOSITES,” JOURNAL OF ARCHIVES IN MILITARY MEDICINE, vol. 5, no. 2, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/350974/en

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