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Information Journal Paper

Title

Effect of High Intensity Interval Training with Flaxseed on Interleukin-1 Beta and Lipocalin-2 Gene Expressions in the Heart Tissue of Rats

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Abstract

 Background: Inflammation plays an important role in the development of atherosclerosis. Interleukin-1 beta (IL-1 ) and lipocalin-2 (LCN-2) are important inflammatory markers in the pathogenesis of atherosclerosis. Objectives: This study aimed to investigate the interactive effects of high intensity interval exercises (HIIT) with Flaxseed Oil consumption on IL-1 and LCN-2 gene expressions in the Heart tissue of rats. Methods: In this experimental study, 20 adult male Wistar rats were randomly selected and divided into four groups of five rats: (1) Control, (2) HIIT, (3) 20 mg/kg of Flaxseed Oil, and (4) HIIT with mg/kg 20 Flaxseed Oil. Groups 2 and 4 ran on a treadmill for 10 weeks and five weeks each, with 90% to 95% intensity of VO2max. For analysis of the research findings, Kolmogorov-Smirnov statistical analysis and two-way ANOVA were used (P 0. 05). Results: Ten weeks of HIIT (P = 0. 001) and Flaxseed Oil consumption (P = 0. 03) had a significant effect on reducing the LCN-2 gene expression in the Heart tissue of rats. However, 10 weeks of HIIT (P = 0. 19) and Flaxseed Oil consumption (P = 0. 19) had no significant effect on IL-1 gene expression in the Heart tissue of rats. In addition, 10 weeks of HIIT with Flaxseed Oil has no interactive effects on IL-1 (P = 0. 91) and LCN-2 (P = 0. 99) in the Heart tissue of rats. Conclusions: Although it seems that the simultaneous use of Flaxseed Oil with HIIT does not have interactive effects on IL-1 and LCN-2 gene expressions in the Heart tissue of rats, the use of Flaxseed Oil and HIIT alone results in improved LCN-2 gene expression in the Heart tissue of rats.

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    APA: Copy

    KHADEMI, YOUNES, HOSSEINI, SEYED ALI, Dana, Fatemeh, AZADMANESH, MAJID, & PIROUZ, MEHDI. (2018). Effect of High Intensity Interval Training with Flaxseed on Interleukin-1 Beta and Lipocalin-2 Gene Expressions in the Heart Tissue of Rats. JOURNAL OF ARCHIVES IN MILITARY MEDICINE, 6(4), 0-0. SID. https://sid.ir/paper/351005/en

    Vancouver: Copy

    KHADEMI YOUNES, HOSSEINI SEYED ALI, Dana Fatemeh, AZADMANESH MAJID, PIROUZ MEHDI. Effect of High Intensity Interval Training with Flaxseed on Interleukin-1 Beta and Lipocalin-2 Gene Expressions in the Heart Tissue of Rats. JOURNAL OF ARCHIVES IN MILITARY MEDICINE[Internet]. 2018;6(4):0-0. Available from: https://sid.ir/paper/351005/en

    IEEE: Copy

    YOUNES KHADEMI, SEYED ALI HOSSEINI, Fatemeh Dana, MAJID AZADMANESH, and MEHDI PIROUZ, “Effect of High Intensity Interval Training with Flaxseed on Interleukin-1 Beta and Lipocalin-2 Gene Expressions in the Heart Tissue of Rats,” JOURNAL OF ARCHIVES IN MILITARY MEDICINE, vol. 6, no. 4, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/351005/en

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