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Title

The Role of Insulin-Like Growth Factor-1 and Pregnancy-Associated Plasma Protein-A in Diagnosis of Acute Coronary Syndrome and Its Related Morbidities

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Abstract

 Introduction: Pregnancy-Associated Plasma Protein-A (PAPP-A) is a metalloproteinase that plays a role in atherosclerotic plaque destabilization. In recent studies, insulin-like growth factor-1 (IGF-1) has been introduced as a mediator of atherosclerosis. PAPP-A and IGF-1 level may be important diagnostic indicators of acute coronary syndrome (ACS). Objective: The present study tried to assess the diagnostic role of IGF-1 and PAPP-A biomarkers in ACS spectrum. Methods: The serum level of IGF-1, PAPP-A and troponin I was determined in 121 consecutive patients with ACS. Relationships were assessed by t-test, ANOVA and the non-parametric equivalent. Accuracy of biomarkers was measured by the area under the ROC curve (AUC) and optimal cut-off points to diagnose STEMI and NSTEMI using Youden index. Results: In patients with acute ST segment elevation myocardial infarction (STEMI), all of these three biomarkers were significantly higher than those in patients with unstable angina (P= 0. 028 for IGF-1, P<0. 001 for PAPP-A and Troponin-I). Mean level of IGF-1 in patients with renal failure was significantly higher than that in patients without renal failure (137. 9± 35. 1 vs 105. 1± 46. 9, P=0. 003), but PAPP-A and serum Troponin-I level had no significant difference in renal failure groups (P>0. 05). ROC curve analysis showed that after Troponin-I, PAPP-A was a good discriminator between patients with STEMI and patients with unstable angina (AUC=0. 79). Optimum cut-off value for PAPP-A was found to be 89. 2 ng/ml, with sensitivity and specificity of 66. 7% and 83. 8%, respectively. Conclusion: PAPP-A can be a novel biomarker for both identification of patients with STEMI and risk stratification in patients with ACS.

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    APA: Copy

    MEHRPOOYA, MARYAM, Malekkandi, Morteza, Arabloo, Mahin, ZEBARDAST, JAYRAN, & Sattartabar, Babak. (2020). The Role of Insulin-Like Growth Factor-1 and Pregnancy-Associated Plasma Protein-A in Diagnosis of Acute Coronary Syndrome and Its Related Morbidities. (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE, 4(2), 0-0. SID. https://sid.ir/paper/351138/en

    Vancouver: Copy

    MEHRPOOYA MARYAM, Malekkandi Morteza, Arabloo Mahin, ZEBARDAST JAYRAN, Sattartabar Babak. The Role of Insulin-Like Growth Factor-1 and Pregnancy-Associated Plasma Protein-A in Diagnosis of Acute Coronary Syndrome and Its Related Morbidities. (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE[Internet]. 2020;4(2):0-0. Available from: https://sid.ir/paper/351138/en

    IEEE: Copy

    MARYAM MEHRPOOYA, Morteza Malekkandi, Mahin Arabloo, JAYRAN ZEBARDAST, and Babak Sattartabar, “The Role of Insulin-Like Growth Factor-1 and Pregnancy-Associated Plasma Protein-A in Diagnosis of Acute Coronary Syndrome and Its Related Morbidities,” (FRONTIERS IN EMERGENCY MEDICINE) ADVANCED JOURNAL OF EMERGENCY MEDICINE, vol. 4, no. 2, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/351138/en

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