ANTILEISHMANIAL ACTIVITY OF MYRTLE METHANOLIC EXTRACT AGAINST LEISHMANIA MAJOR: AN IN VITRO STUDY

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MAHMOUDVAND HOSSEIN; SALEHI LALEHMARZI HAMED; FALLAHI SHIRZAD; MOSLEHI BAHARANCHI MARYAM; BAYAT PARDIS; JAHANBAKHSH SAREH

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Journal: Herbal Medicines Journal Year:2017 | Volume:2 | Issue:3 Page(s): 122-125

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Title

ANTILEISHMANIAL ACTIVITY OF MYRTLE METHANOLIC EXTRACT AGAINST LEISHMANIA MAJOR: AN IN VITRO STUDY

Author(s)

Keywords

PROMASTIGOTE

AMASTIGOTE

LEISHMANIA MAJOR

MEDICINAL PLANTS

CUTANEOUS LEISHMANIASIS

MYRTUS COMMUNIS

Abstract

Background and Aim: In this study we assessed the in vitro antileishmanial activity of myrtle (Myrtus communis L.) methanolic extract against LEISHMANIA MAJOR.Materials and Methods: The in vitro antileishmanial effects of myrtle methanolic extract against L. major PROMASTIGOTE and AMASTIGOTEs were determined by colorimetric cell viability (MTT) assay and macrophage model, respectively. The IC50 values were also calculated by probit test in SPSS software.Results: The obtained results showed that myrtle extract was significantly inhibited PROMASTIGOTE growth of L. major based on a dose and time dependent manner. The measured IC50 values for myrtle methanolic extract and MA as control drug against PROMASTIGOTE forms of L. major were 23.6 mg/mL and 88.3 mg/mL, respectively. The obtained IC50 values were 13.8 mg/mL and 44.6 mg/mL for the myrtle essential oil and MA, respectively.Conclusion: This investigation showed antileishmanial effect of myrtle against PROMASTIGOTE and AMASTIGOTE forms of L. major. However, further studies are needed to confirm these results by checking in the animal models and volunteer human.

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APA: Copy

MAHMOUDVAND, HOSSEIN, SALEHI LALEHMARZI, HAMED, FALLAHI, SHIRZAD, MOSLEHI BAHARANCHI, MARYAM, BAYAT, PARDIS, & JAHANBAKHSH, SAREH. (2017). ANTILEISHMANIAL ACTIVITY OF MYRTLE METHANOLIC EXTRACT AGAINST LEISHMANIA MAJOR: AN IN VITRO STUDY. HERBAL MEDICINES JOURNAL, 2(3 ), 122-125. SID. https://sid.ir/paper/351297/en

Vancouver: Copy

MAHMOUDVAND HOSSEIN, SALEHI LALEHMARZI HAMED, FALLAHI SHIRZAD, MOSLEHI BAHARANCHI MARYAM, BAYAT PARDIS, JAHANBAKHSH SAREH. ANTILEISHMANIAL ACTIVITY OF MYRTLE METHANOLIC EXTRACT AGAINST LEISHMANIA MAJOR: AN IN VITRO STUDY. HERBAL MEDICINES JOURNAL[Internet]. 2017;2(3 ):122-125. Available from: https://sid.ir/paper/351297/en

IEEE: Copy

HOSSEIN MAHMOUDVAND, HAMED SALEHI LALEHMARZI, SHIRZAD FALLAHI, MARYAM MOSLEHI BAHARANCHI, PARDIS BAYAT, and SAREH JAHANBAKHSH, “ANTILEISHMANIAL ACTIVITY OF MYRTLE METHANOLIC EXTRACT AGAINST LEISHMANIA MAJOR: AN IN VITRO STUDY,” HERBAL MEDICINES JOURNAL, vol. 2, no. 3 , pp. 122–125, 2017, [Online]. Available: https://sid.ir/paper/351297/en

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