METHOD VALIDATION OF METHOTREXATE IN HUMAN PLASMA BY LC-MS TECHNIQUE IN PATIENTS WITH BRAIN TUMOUR

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DANAFAR HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Epidemiology and Health System Journal Year:2016 | Volume:3 | Issue:2 Page(s): 162-171

Download Full-Text

View:

211

Download:

143

Cites:

Information Journal Paper

Title

METHOD VALIDATION OF METHOTREXATE IN HUMAN PLASMA BY LC-MS TECHNIQUE IN PATIENTS WITH BRAIN TUMOUR

Author(s)

DANAFAR HOSSEIN | Issue Writer Certificate

Keywords

METHOTREXATE

LC-MS

HUMAN PLASMA

Abstract

Background and aims: A selective and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been established for determination of METHOTREXATE in HUMAN PLASMA.Methods: METHOTREXATE was extracted from plasma with acetonitrile. The mobile phase consisted of acetonitrile- water- formic acid 74: 25: 1 (v/v). Twenty ml of sample was chromatographically analyzed using a repacked ZORBAX-XDB-ODS C18 column (2.1mm×30mm, 3.5 micron). The mode of mass spectrometry was selected-ion monitoring (SIM).Results: Standard curve was linear (r=0.998) over the concentration range of 0.1–100.0 ng/ml and showed a suitable accuracy and precision. The limit of detection (LOD) was 0.05ng/ml.Conclusion: The method is quick, easy, very steady and precise for the partition, assignment and evaluation of METHOTREXATE in HUMAN PLASMA.

Cites

No record.

References

No record.

Cite

APA: Copy

DANAFAR, HOSSEIN. (2016). METHOD VALIDATION OF METHOTREXATE IN HUMAN PLASMA BY LC-MS TECHNIQUE IN PATIENTS WITH BRAIN TUMOUR. EPIDEMIOLOGY AND HEALTH SYSTEM JOURNAL (INTERNATIONAL JOURNAL OF EPIDEMIOLOGIC RESEARCH), 3(2), 162-171. SID. https://sid.ir/paper/351343/en

Vancouver: Copy

DANAFAR HOSSEIN. METHOD VALIDATION OF METHOTREXATE IN HUMAN PLASMA BY LC-MS TECHNIQUE IN PATIENTS WITH BRAIN TUMOUR. EPIDEMIOLOGY AND HEALTH SYSTEM JOURNAL (INTERNATIONAL JOURNAL OF EPIDEMIOLOGIC RESEARCH)[Internet]. 2016;3(2):162-171. Available from: https://sid.ir/paper/351343/en

IEEE: Copy

HOSSEIN DANAFAR, “METHOD VALIDATION OF METHOTREXATE IN HUMAN PLASMA BY LC-MS TECHNIQUE IN PATIENTS WITH BRAIN TUMOUR,” EPIDEMIOLOGY AND HEALTH SYSTEM JOURNAL (INTERNATIONAL JOURNAL OF EPIDEMIOLOGIC RESEARCH), vol. 3, no. 2, pp. 162–171, 2016, [Online]. Available: https://sid.ir/paper/351343/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops