COMPARING THE EFFICACY OF DEXMEDETOMIDINE VERSUS FENTANYL AND MIDAZOLAM DURING AWAKE FIBEROPTIC INTUBATION

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HASSANI VALIOLLAH; FARHADI MOHAMMAD; MOHSENI MASOOD; SAFAEIAN REZA; NIKOUBAKHT NASIM; SEHAT KASHANI SALOOMEH; FARAHMAND RAD REZA; POURKAND SHAYESTEH; MOHEBBI ELHAM

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Journal: Archives of Anesthesiology and Critical Care Year:2018 | Volume:4 | Issue:4 Page(s): 538-541

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Title

COMPARING THE EFFICACY OF DEXMEDETOMIDINE VERSUS FENTANYL AND MIDAZOLAM DURING AWAKE FIBEROPTIC INTUBATION

Author(s)

Keywords

AWAKE FIBEROPTIC INTUBATION

DEXMEDETOMIDINE

MIDAZOLAM

FENTANYL

Abstract

Background: Awake oral flexible fiberoptic intubation (AFOI) is used in patients with expected difficult airways. Different drugs have been used for sedation and yet we need to define ideal drug with proper sedation and safety, less changes in hemodynamic stability and less airway compromise. We aimed to compare the efficacy of DEXMEDETOMIDINE with FENTANYL and MIDAZOLAM during AFOI.Methods: In this randomized clinical trial, 52 patients undergoing elective surgery and candidate for AFOI were randomly allocated to two groups. First group received 1mcg/kg of DEXMEDETOMIDINE in 10 minutes and then infusion of 0.5 mcg/kg/h and second group received 2 mcg/kg FENTANYL and then 1 mg MIDAZOLAM. Hemodynamic variables, O2 saturation (SpO2) were evaluated before and after sedation and after intubation. Ramsey sedation scale (RSS) and patient’s tolerance were evaluated during bronchoscopy and intubation.Results: Lower heart rate after intubation (p=0.008) and higher SpO2 before sedation (p<0.001) and after intubation (p=0.02) were observed in DEXMEDETOMIDINE group compared to FENTANYL group. The need for propofol for further sedation was comparable between groups (11.5% vs. 7.7%, respectively; p=0.63). Both groups had comparable RSS and tolerance during intubation.Conclusion: DEXMEDETOMIDINE compared to FENTANYL and MIDAZOLAM had comparable sedation with better hemodynamic stability and O2 saturation during AFOI.

Cites

Effects of Midazolam and Dexmedetomidine on Sedation Levels, Hemodynamics and, Complications under Brain Stereotaxic Surgery

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APA: Copy

HASSANI, VALIOLLAH, FARHADI, MOHAMMAD, MOHSENI, MASOOD, SAFAEIAN, REZA, NIKOUBAKHT, NASIM, SEHAT KASHANI, SALOOMEH, FARAHMAND RAD, REZA, MOHEBBI, ELHAM, & POURKAND, SHAYESTEH. (2018). COMPARING THE EFFICACY OF DEXMEDETOMIDINE VERSUS FENTANYL AND MIDAZOLAM DURING AWAKE FIBEROPTIC INTUBATION. ARCHIVES OF ANESTHESIOLOGY AND CRITICAL CARE, 4(4), 538-541. SID. https://sid.ir/paper/352482/en

Vancouver: Copy

HASSANI VALIOLLAH, FARHADI MOHAMMAD, MOHSENI MASOOD, SAFAEIAN REZA, NIKOUBAKHT NASIM, SEHAT KASHANI SALOOMEH, FARAHMAND RAD REZA, MOHEBBI ELHAM, POURKAND SHAYESTEH. COMPARING THE EFFICACY OF DEXMEDETOMIDINE VERSUS FENTANYL AND MIDAZOLAM DURING AWAKE FIBEROPTIC INTUBATION. ARCHIVES OF ANESTHESIOLOGY AND CRITICAL CARE[Internet]. 2018;4(4):538-541. Available from: https://sid.ir/paper/352482/en

IEEE: Copy

VALIOLLAH HASSANI, MOHAMMAD FARHADI, MASOOD MOHSENI, REZA SAFAEIAN, NASIM NIKOUBAKHT, SALOOMEH SEHAT KASHANI, REZA FARAHMAND RAD, ELHAM MOHEBBI, and SHAYESTEH POURKAND, “COMPARING THE EFFICACY OF DEXMEDETOMIDINE VERSUS FENTANYL AND MIDAZOLAM DURING AWAKE FIBEROPTIC INTUBATION,” ARCHIVES OF ANESTHESIOLOGY AND CRITICAL CARE, vol. 4, no. 4, pp. 538–541, 2018, [Online]. Available: https://sid.ir/paper/352482/en

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