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Information Journal Paper

Title

DESIGN AND PERFORMANCE INVESTIGATION OF ELECTROSPUN PVA NANOFIBERS CONTAINING CORE-SHELL NANOSTRUCTURES FOR ANTICANCER DRUG DELIVERY

Pages

  31-36

Abstract

 Objective: The purpose of this work was design and performance investigation of a nanocarrier based on magnetic nanofibers containing CORE-SHELL NANOSTRUCTUREs for anticancer drug delivery of DAUNORUBICIN (DAN) by measuring their DRUG RELEASE at different pH values.Methods: Fe3O4 nanoparticles and Fe3O4@SiO2CORE-SHELL NANOSTRUCTUREs were synthesized through coprecipitation and Stöber method respectively. The composite nanofibers of polyvinyl alcohol containing CORE-SHELL NANOSTRUCTUREs and anticancer drug of DAUNORUBICIN were fabricated by electro spinning method. The nanostructures were characterized by SEM, XRD, VSM and FTIR techniques. The DRUG RELEASE was investigated by UV-Vis spectrophotometer at different pHs.Results: The results is shown that in vitro DRUG RELEASE at pH=6.0 is promisingly more and faster than DRUG RELEASE at pH=7.4. The fitted equation of release curves is corresponded to Peppas model.Conclusions: It can be concluded that the proposed nanocarrier is capable of responding to pH changes, that is an advantage in the targeted delivery of the drug. Also, this method has the advantages of magnetic sensitivity, high drug loading capacity and sustained release.

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    • Cite

    APA: Copy

    KAVYANIFAR, SAKINEH, SHAMSPUR, TAYEBEH, Fathirad, Fariba, & MOSTAFAVI, ALI. (2018). DESIGN AND PERFORMANCE INVESTIGATION OF ELECTROSPUN PVA NANOFIBERS CONTAINING CORE-SHELL NANOSTRUCTURES FOR ANTICANCER DRUG DELIVERY. NANOMEDICINE RESEARCH JOURNAL, 3(1), 31-36. SID. https://sid.ir/paper/352778/en

    Vancouver: Copy

    KAVYANIFAR SAKINEH, SHAMSPUR TAYEBEH, Fathirad Fariba, MOSTAFAVI ALI. DESIGN AND PERFORMANCE INVESTIGATION OF ELECTROSPUN PVA NANOFIBERS CONTAINING CORE-SHELL NANOSTRUCTURES FOR ANTICANCER DRUG DELIVERY. NANOMEDICINE RESEARCH JOURNAL[Internet]. 2018;3(1):31-36. Available from: https://sid.ir/paper/352778/en

    IEEE: Copy

    SAKINEH KAVYANIFAR, TAYEBEH SHAMSPUR, Fariba Fathirad, and ALI MOSTAFAVI, “DESIGN AND PERFORMANCE INVESTIGATION OF ELECTROSPUN PVA NANOFIBERS CONTAINING CORE-SHELL NANOSTRUCTURES FOR ANTICANCER DRUG DELIVERY,” NANOMEDICINE RESEARCH JOURNAL, vol. 3, no. 1, pp. 31–36, 2018, [Online]. Available: https://sid.ir/paper/352778/en

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