IN SILICO ANALYSIS OF A MULTI-SUBUNIT IMMUNOGEN, TARGETING VIRULENCE FACTORS OF ENTEROHEMORRHAGIC ESCHERICHIA COLI

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KORDBACHEH EMAD; NAZARIAN SHAHRAM; AMERIAN MILAD

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Journal: JOURNAL OF APPLIED BIOTECHNOLOGY REPORTS Year:2017 | Volume:4 | Issue:2 Page(s): 593-602

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Title

IN SILICO ANALYSIS OF A MULTI-SUBUNIT IMMUNOGEN, TARGETING VIRULENCE FACTORS OF ENTEROHEMORRHAGIC ESCHERICHIA COLI

Author(s)

KORDBACHEH EMAD | NAZARIAN SHAHRAM | AMERIAN MILAD | Issue Writer Certificate

Keywords

BIOINFORMATICS; CHIMERIC PROTEIN; VIRULENCE FACTORS; ENTEROHEMORRHAGIC E. COLI

Abstract

Enterohemorrhagic Escherichia coli (EHEC) strains are foodborne pathogens withimportance in public health. The lack of effective clinical treatment, sequelae afterinfection and mortality rate in humans confirms the essential need for prophylacticand vaccines approaches. EspA, Tir, HcpA and Stx2 are major virulence factors foradherence and toxicity of EHEC, so an appropriate tetravalent immunogen consistof toxin subunit and crucial colonization factors was selected and constructed. Bioinformaticanalyses of recombinant construction such as sequences choosing andoptimizing, mRNA folding, physicochemical property in 2D and 3D structures,besides other immunoinformatics data like B-cell and T-cell epitopes and allergenicityof chimera were some reported according to the reliable servers. In silicoassessment of the chimeric proteins demonstrated the desired model has a propermRNA features, besides acceptable stability and solubility. This model is close tonative proteins topologically, and all domains were found to have a high antigeniccompetency and surface accessibility. These results can be beneficial for the developmentof a chimeric immunogen against adherence and toxicity of EHEC in ananimal model application.

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APA: Copy

KORDBACHEH, EMAD, NAZARIAN, SHAHRAM, & AMERIAN, MILAD. (2017). IN SILICO ANALYSIS OF A MULTI-SUBUNIT IMMUNOGEN, TARGETING VIRULENCE FACTORS OF ENTEROHEMORRHAGIC ESCHERICHIA COLI. JOURNAL OF APPLIED BIOTECHNOLOGY REPORTS, 4(2), 593-602. SID. https://sid.ir/paper/352954/en

Vancouver: Copy

KORDBACHEH EMAD, NAZARIAN SHAHRAM, AMERIAN MILAD. IN SILICO ANALYSIS OF A MULTI-SUBUNIT IMMUNOGEN, TARGETING VIRULENCE FACTORS OF ENTEROHEMORRHAGIC ESCHERICHIA COLI. JOURNAL OF APPLIED BIOTECHNOLOGY REPORTS[Internet]. 2017;4(2):593-602. Available from: https://sid.ir/paper/352954/en

IEEE: Copy

EMAD KORDBACHEH, SHAHRAM NAZARIAN, and MILAD AMERIAN, “IN SILICO ANALYSIS OF A MULTI-SUBUNIT IMMUNOGEN, TARGETING VIRULENCE FACTORS OF ENTEROHEMORRHAGIC ESCHERICHIA COLI,” JOURNAL OF APPLIED BIOTECHNOLOGY REPORTS, vol. 4, no. 2, pp. 593–602, 2017, [Online]. Available: https://sid.ir/paper/352954/en

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