Association between IRF6 rs642961 Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate Risk in an Iranian Population

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Niktabar Seyed Mohammadreza; Amooee Abdolhamid; Piroozmand Parisa; Farahnak Soudabeh; Foroughi Elnaz; Latifi Seyed Mojtaba; NEAMATZADEH HOSSEIN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: WORLD JOURNAL OF PERI AND NEONATOLOGY Year:2018 | Volume:1 | Issue:1 Page(s): 30-35

Download Full-Text

View:

149

Download:

Cites:

Information Journal Paper

Title

Association between IRF6 rs642961 Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate Risk in an Iranian Population

Author(s)

Keywords

Nonsyndromic

Cleft lip

Cleft palate

Interferon regulatory factor 6

Polymorphism

Abstract

Background: The extent of the contribution of rs642961 Polymorphism of interferon regulatory factor-6 (IRF6) gene with susceptibility to the syndromic Cleft lip with or without Cleft palate (NSCL/P) in the Iranian patients is still unknown. Thus, to test the role of IRF6 in NSCL/P susceptibility in an Iranian population, we performed a population based case-control stud. Methods: One-hundred ten patients with NSCL/P and 110 matched healthy subjects were recruited to this population-based study. The IRF6 rs642961 Polymorphism was genotyped by polymerase chain reaction-restriction fragment length Polymorphism (PCR-RFLP) assay. Results: Participants did not differ significantly by age and gender (P > 0. 05). The AA, AG, and GG genotypes frequencies of the IRF6 rs642961 Polymorphism in the NSCL/P cases were 27. 3%, 53. 6% and 19. 1%, respectively while the corresponding frequencies in the healthy subjects were 34. 5, 56. 4% and 9. 1%, respectively. There was a significant association between homozygote mutant genotype (GG) of IRF6 rs642961 Polymorphism and increased risk of NSCL/P (OR = 2. 360, 95% CI 1. 055-5. 280, P = 0. 037). Conclusion: the current study suggested that IRF6 rs642961 Polymorphism might be associated with susceptibility to NSCL/P in an Iranian population. However, well-designed epidemiological studies with larger sample size are needed to further validate our results.

Cites

No record.

References

No record.

Cite

APA: Copy

Niktabar, Seyed Mohammadreza, Amooee, Abdolhamid, Piroozmand, Parisa, Farahnak, Soudabeh, Foroughi, Elnaz, Latifi, Seyed Mojtaba, & NEAMATZADEH, HOSSEIN. (2018). Association between IRF6 rs642961 Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate Risk in an Iranian Population. WORLD JOURNAL OF PERI AND NEONATOLOGY, 1(1), 30-35. SID. https://sid.ir/paper/355060/en

Vancouver: Copy

Niktabar Seyed Mohammadreza, Amooee Abdolhamid, Piroozmand Parisa, Farahnak Soudabeh, Foroughi Elnaz, Latifi Seyed Mojtaba, NEAMATZADEH HOSSEIN. Association between IRF6 rs642961 Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate Risk in an Iranian Population. WORLD JOURNAL OF PERI AND NEONATOLOGY[Internet]. 2018;1(1):30-35. Available from: https://sid.ir/paper/355060/en

IEEE: Copy

Seyed Mohammadreza Niktabar, Abdolhamid Amooee, Parisa Piroozmand, Soudabeh Farahnak, Elnaz Foroughi, Seyed Mojtaba Latifi, and HOSSEIN NEAMATZADEH, “Association between IRF6 rs642961 Polymorphism and Nonsyndromic Cleft Lip with or without Cleft Palate Risk in an Iranian Population,” WORLD JOURNAL OF PERI AND NEONATOLOGY, vol. 1, no. 1, pp. 30–35, 2018, [Online]. Available: https://sid.ir/paper/355060/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops