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Title

Serum level of melatonin in patients with osteoarthritis and its relation with 8-hydroxy-2-deoxyguanosine and vitamin D

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Abstract

 Introduction: This study aimed to evaluate the relationship between the serum level of Melatonin, 8-hydroxy-2-deoxy guanosine, and vitamin-D in patients with Osteoarthritis (OA). Methods: This study enrolled 47 patients with OA and 40 healthy controls. Serum levels of Melatonin and 8-hydroxy-2-deoxy guanosine (8-OH-dG) were assessed. Also, serum levels of bone turnover biomarkers such as calcium, phosphorus, vitamin D, and alkaline phosphatase (ALP) were measured in OA patients and controls. Results: The serum level of Melatonin was significantly lower in OA patients than the controls (6. 18 ± 2. 25 vs. 11. 57 ± 3. 87 pg/mL, P < 0. 05). In contrast, the serum level of 8-OH-dG was significantly increased in OA patients compared to controls (65. 21 ± 16. 12 vs. 22. 51 ± 5. 3 ng/dL, P < 0. 001). There was a negative correlation between serum Melatonin and 8-OHdG levels in OA patients (P < 0. 05). There was a positive correlation between serum Melatonin and vitamin D levels in OA patients (P < 0. 05). We found decreased calcium and vitamin D levels, and increased phosphorus and ALP levels in OA patients compared to controls (P < 0. 05). Conclusion: Decreased levels of Melatonin and elevated levels of 8-OH-dG might play a role in the pathogenesis of OA. Therefore, Melatonin might be involved in decreasing DNA damage and exerting a preventive function in OA.

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    APA: Copy

    Asanjani Oskoii, Meisagh, Khatami, Nasrin, MAJIDINIA, MARYAM, Rezazadeh, Mohammad Amin, MIR, SEYED MOSTAFA, SADEGHPOUR, ALIREZA, & YOUSEFI, BAHMAN. (2020). Serum level of melatonin in patients with osteoarthritis and its relation with 8-hydroxy-2-deoxyguanosine and vitamin D. JOURNAL OF RESEARCH IN CLINICAL MEDICINE, 8(1), 0-0. SID. https://sid.ir/paper/355199/en

    Vancouver: Copy

    Asanjani Oskoii Meisagh, Khatami Nasrin, MAJIDINIA MARYAM, Rezazadeh Mohammad Amin, MIR SEYED MOSTAFA, SADEGHPOUR ALIREZA, YOUSEFI BAHMAN. Serum level of melatonin in patients with osteoarthritis and its relation with 8-hydroxy-2-deoxyguanosine and vitamin D. JOURNAL OF RESEARCH IN CLINICAL MEDICINE[Internet]. 2020;8(1):0-0. Available from: https://sid.ir/paper/355199/en

    IEEE: Copy

    Meisagh Asanjani Oskoii, Nasrin Khatami, MARYAM MAJIDINIA, Mohammad Amin Rezazadeh, SEYED MOSTAFA MIR, ALIREZA SADEGHPOUR, and BAHMAN YOUSEFI, “Serum level of melatonin in patients with osteoarthritis and its relation with 8-hydroxy-2-deoxyguanosine and vitamin D,” JOURNAL OF RESEARCH IN CLINICAL MEDICINE, vol. 8, no. 1, pp. 0–0, 2020, [Online]. Available: https://sid.ir/paper/355199/en

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