THE ROLE OF ACUTE STRESS AND GLUCOCORTICOIDS IN WITHDRAWAL SYNDROME SINGS IN MORPHINE DEPENDENT MICE

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TAHERIAN ABAS ALI; VAFAEI A.A.; RASHIDIPOUR A.

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Journal: Koomesh Year:2003 | Volume:4 | Issue:3-4 Page(s): 137-142

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Title

THE ROLE OF ACUTE STRESS AND GLUCOCORTICOIDS IN WITHDRAWAL SYNDROME SINGS IN MORPHINE DEPENDENT MICE

Author(s)

TAHERIAN ABAS ALI | VAFAEI A.A. | RASHIDIPOUR A. | Issue Writer Certificate

Keywords

STRESSQ2

DEXAMETHASONEQ3

DEPENDENCYQ2

MICEQ2

NALOXONEQ2

WITHDRAWAL SYNDROMEQ3

Abstract

Introduction: Tolerance and DEPENDENCY are two main problems that have limited morphine administration. There are some evidences indicating that glucocorticoids and STRESS may play a role in morphine-induced tolerance and DEPENDENCY. Materials and methods: In this study, Male albinos MICE (25 30 gr.) were used. Morphine DEPENDENCY was induced by Marshall method. On test day (day 4), NALOXONE (2 mg/kg, IP) was injected to induce WITHDRAWAL SYNDROME (WS) signs. Jumping and loss of weight were used as indexes of WS signs. Dexametasone was injected 30 min before induction of WS by NALOXONE. The rat was STRESSed in cold water for 1min 3 min before induction of WS. Results: The results show that DEXAMETHASONE and STRESS significantly diminish WS signs and the effect of STRESS was significantly higher than that of DEXAMETHASONE. Conclusion: The data indicate that glucocorticoids and STRESS may play an important role in morphine addiction process.

Cites

EFFECT OF STRESS ON MORPHINE WITHDRAWAL SIGNS IN RATS

References

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APA: Copy

TAHERIAN, ABAS ALI, VAFAEI, A.A., & RASHIDIPOUR, A.. (2003). THE ROLE OF ACUTE STRESS AND GLUCOCORTICOIDS IN WITHDRAWAL SYNDROME SINGS IN MORPHINE DEPENDENT MICE. KOOMESH, 4(3-4), 137-142. SID. https://sid.ir/paper/356170/en

Vancouver: Copy

TAHERIAN ABAS ALI, VAFAEI A.A., RASHIDIPOUR A.. THE ROLE OF ACUTE STRESS AND GLUCOCORTICOIDS IN WITHDRAWAL SYNDROME SINGS IN MORPHINE DEPENDENT MICE. KOOMESH[Internet]. 2003;4(3-4):137-142. Available from: https://sid.ir/paper/356170/en

IEEE: Copy

ABAS ALI TAHERIAN, A.A. VAFAEI, and A. RASHIDIPOUR, “THE ROLE OF ACUTE STRESS AND GLUCOCORTICOIDS IN WITHDRAWAL SYNDROME SINGS IN MORPHINE DEPENDENT MICE,” KOOMESH, vol. 4, no. 3-4, pp. 137–142, 2003, [Online]. Available: https://sid.ir/paper/356170/en

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