EVALUATING THE EFFICACY OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN THE DIAGNOSIS OF RHEUMATOID ARTHRITIS DISEASE

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ZAMANI B.; ESALATMANESH KAMAL; FAKHRZAD A.R.; EHTERAMI HASAN; MOUSAVI SEYED GHOLAM ABAS; ARBABI MOHSEN

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Journal: Feyz Medical Sciences Journal Year:2010 | Volume:13 | Issue:4 (SERIAL 52) Page(s): 278-284

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Title

EVALUATING THE EFFICACY OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN THE DIAGNOSIS OF RHEUMATOID ARTHRITIS DISEASE

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Keywords

RHEUMATOID ARTHRITISQ2

RHEUMATOID FACTORQ2

ANTI-CYCLIC CITRULLINATED PEPTIDEQ3

SENSITIVITY AND SPECIFICITYQ3

PREDICTIVE VALUE OF TESTSQ3

Abstract

Background: RHEUMATOID ARTHRITIS is one of the most common autoimmune diseases. Early diagnosis can prevent side effects and disability. ANTI-CYCLIC CITRULLINATED PEPTIDE antibody is a specific marker to diagnose RHEUMATOID ARTHRITIS. This study was carried out to evaluate the efficacy of ANTI-CYCLIC CITRULLINATED PEPTIDE in comparison with RHEUMATOID FACTOR in RHEUMATOID ARTHRITIS patients referred to Behshti Hospital of Kashan city during 2006-7.Materials and Methods: This diagnostic value study was done on 98 randomly selected RHEUMATOID ARTHRITIS patients and 75 patients with other rheumatic diseases. In this study RHEUMATOID FACTOR titer>35 IU/ml and ANTI-CYCLIC CITRULLINATED PEPTIDE>6.25 IU/ml were considered positive.Results: ANTI-CYCLIC CITRULLINATED PEPTIDE compared to RHEUMATOID FACTOR had a higher sensitivity (73.5% vs. 69.4%), specificity (88% vs. 84%), positive predictive value (88.9% vs. 85%), and negative predictive value (71.7% vs. 67.7%) for RHEUMATOID ARTHRITIS. The use of RHEUMATOID FACTOR and ANTI-CYCLIC CITRULLINATED PEPTIDE test together increased the specificity and positive predictive value for diagnosis of RHEUMATOID ARTHRITIS to 93.3% and 92.4%, respectively. The mean ANTI-CYCLIC CITRULLINATED PEPTIDE showed a significant difference in RHEUMATOID ARTHRITIS (46.8 IU/ml) in comparison to non RHEUMATOID ARTHRITIS patients (5.3 IU/ml).Conclusion: ANTI-CYCLIC CITRULLINATED PEPTIDE had a better diagnostic value when compared to RHEUMATOID FACTOR for detection of RHEUMATOID ARTHRITIS. Also combined use of RHEUMATOID FACTOR and ANTI-CYCLIC CITRULLINATED PEPTIDE had a higher specificity and positive predictive value than each alone for the diagnosis of RHEUMATOID ARTHRITIS.

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APA: Copy

ZAMANI, B., ESALATMANESH, KAMAL, FAKHRZAD, A.R., EHTERAMI, HASAN, MOUSAVI, SEYED GHOLAM ABAS, & ARBABI, MOHSEN. (2010). EVALUATING THE EFFICACY OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN THE DIAGNOSIS OF RHEUMATOID ARTHRITIS DISEASE. FEYZ, 13(4 (SERIAL 52)), 278-284. SID. https://sid.ir/paper/356179/en

Vancouver: Copy

ZAMANI B., ESALATMANESH KAMAL, FAKHRZAD A.R., EHTERAMI HASAN, MOUSAVI SEYED GHOLAM ABAS, ARBABI MOHSEN. EVALUATING THE EFFICACY OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN THE DIAGNOSIS OF RHEUMATOID ARTHRITIS DISEASE. FEYZ[Internet]. 2010;13(4 (SERIAL 52)):278-284. Available from: https://sid.ir/paper/356179/en

IEEE: Copy

B. ZAMANI, KAMAL ESALATMANESH, A.R. FAKHRZAD, HASAN EHTERAMI, SEYED GHOLAM ABAS MOUSAVI, and MOHSEN ARBABI, “EVALUATING THE EFFICACY OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODY IN THE DIAGNOSIS OF RHEUMATOID ARTHRITIS DISEASE,” FEYZ, vol. 13, no. 4 (SERIAL 52), pp. 278–284, 2010, [Online]. Available: https://sid.ir/paper/356179/en

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