THE ACQUEOUS EXTRACT OF CROCUS SATIVUS STIGMA REDUCES MORPHINE TOLERANCE

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SHAMS J.; MOULAVI S.; MARJANI S.; KAMALINEZHAD MOHAMMAD; ZARDOUZ H.; SAHRAEI HEDAYAT; NOUROUZZADEH ALI

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Journal: Physiology and Pharmacology Year:2009 | Volume:13 | Issue:2 Page(s): 178-180

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Title

THE ACQUEOUS EXTRACT OF CROCUS SATIVUS STIGMA REDUCES MORPHINE TOLERANCE

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Keywords

MORPHINEQ3

CROCUS SATIVUSQ3

ANALGESIAQ3

TOLERANCEQ3

Abstract

Introduction: Previous studies in male and female mice have shown that administration of saffron extract could induce reward and reduce MORPHINE reward as investigated by place preference and behavioral sensitization. In the present study, the effects of water extract of CROCUS SATIVUS on the acquisition and expression of TOLERANCE to MORPHINEinduced hyperalgesia in female N-MRI mice (20-25 g) were investigated.Methods: Tail Flick technique was used in the present study. MORPHINE TOLERANCE was achieved by MORPHINE injections 50 mg/kg, twice daily for 3 consecutive days. On the 4th day of the experiments, MORPHINE TOLERANCE was assessed in animals by injection of effective dose of MORPHINE (10 mg/kg). The extract of the C. sativus was administered during or after the induction of MORPHINE TOLERANCE, to assess its effect on the development and expression of TOLERANCE, respectively. Results: Results showed that administration of MORPHINE (1, 5, 10 and 20 mg/kg), induced significant ANALGESIA in mice. Administration of the plant extract (1, 2.5, 5, 10, 50 and 100 mg/kg) also produced ANALGESIA, which was statistically significant with the 10 mg/kg dose. Injection of saffron extracts (1, 2.5 and 5 mg/kg) on the test day, 30 min before MORPHINE administration (10 mg/kg) reduced the expression of MORPHINE TOLERANCE. However, administration of the extract (1, 2.5 and 5 mg/kg) during the induction of MORPHINE TOLERANCE, did not have any effect on the development of MORPHINE TOLERANCE.Conclusion: It could be concluded that injection of the extract of C. sativus can inhibit the expression but cannot alter the acquisition of MORPHINE TOLERANCE. In addition, administration of the extract alone could also induce ANALGESIA.

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EVALUATION OF THE EFFECT OF ORAL SAFFRON CAPSULES ON PAIN INTENSITY DURING THE ACTIVE PHASE OF LABOR

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APA: Copy

SHAMS, J., MOULAVI, S., MARJANI, S., KAMALINEZHAD, MOHAMMAD, ZARDOUZ, H., SAHRAEI, HEDAYAT, & NOUROUZZADEH, ALI. (2009). THE ACQUEOUS EXTRACT OF CROCUS SATIVUS STIGMA REDUCES MORPHINE TOLERANCE. PHYSIOLOGY AND PHARMACOLOGY, 13(2), 178-180. SID. https://sid.ir/paper/356314/en

Vancouver: Copy

SHAMS J., MOULAVI S., MARJANI S., KAMALINEZHAD MOHAMMAD, ZARDOUZ H., SAHRAEI HEDAYAT, NOUROUZZADEH ALI. THE ACQUEOUS EXTRACT OF CROCUS SATIVUS STIGMA REDUCES MORPHINE TOLERANCE. PHYSIOLOGY AND PHARMACOLOGY[Internet]. 2009;13(2):178-180. Available from: https://sid.ir/paper/356314/en

IEEE: Copy

J. SHAMS, S. MOULAVI, S. MARJANI, MOHAMMAD KAMALINEZHAD, H. ZARDOUZ, HEDAYAT SAHRAEI, and ALI NOUROUZZADEH, “THE ACQUEOUS EXTRACT OF CROCUS SATIVUS STIGMA REDUCES MORPHINE TOLERANCE,” PHYSIOLOGY AND PHARMACOLOGY, vol. 13, no. 2, pp. 178–180, 2009, [Online]. Available: https://sid.ir/paper/356314/en

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