EFFECT OF EPHEDRINE ON MORPHINE ANTINOCICEPTION AND TOLERANCE INDUCED TO MORPHINE ANTINOCICEPTION IN MICE

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HABIBIASL B.; SOLTANI R.

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Journal: PHARMACEUTICAL SCIENCES Year:2005 | Volume:- | Issue:2 Page(s): 11-15

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Title

EFFECT OF EPHEDRINE ON MORPHINE ANTINOCICEPTION AND TOLERANCE INDUCED TO MORPHINE ANTINOCICEPTION IN MICE

Author(s)

HABIBIASL B. | SOLTANI R. | Issue Writer Certificate

Keywords

MORPHINEQ2

TOLERANCEQ2

ANTINOCICEPTIONQ2

EPHEDRINEQ2

Abstract

OBJECTIVES: In the previous study it has been shown that adrenergic drugs have antinociceptive effect. EPHEDRINE (ephedrine sulfate) is both an a and a β adrenergic agonist; in addition, it enhances release of norepinephrine from sympathetic neurons. Opioids have different side effects, particularly respiratory depression and dependency. The purpose of the present study was to determine the possible action of EPHEDRINE on MORPHINE ANTINOCICEPTION and TOLERANCE induced to MORPHINE ANTINOCICEPTION. METHODS: To measure ANTINOCICEPTION, different doses of MORPHINE (3, 6 and 9 mg/kg, ip), EPHEDRINE (10, 20, 30 mg/kg, ip) and EPHEDRINE (10, 20, 30 mg/kg,ip)+MORPHINE (3,6 mg/kg, ip) were injected. To develop a TOLERANCE to MORPHINE, ANTINOCICEPTION animals received MORPHINE (30 mg/kg, ip) once a day for four days. A test dose of MORPHINE (9 mg/kg, ip) was tested on day 5 (24 h after the last dose of 50 mg/kg MORPHINE). RESULTS: Intraperitoneal (ip) injection of different doses of MORPHINE (3, 6 and 9 mg/kg, ip), EPHEDRINE (10, 20, 30 mg/kg, ip) induced a dose dependent ANTINOCICEPTION. The responses induced by MORPHINE were increased by EPHEDRINE. MORPHINE (3mg/kg, ip) in combination with EPHEDRINE (10 mg/kg, ip) tended to elicit higher response (equal to MORPHINE 6 mg/kg). Different doses of EPHEDRINE (10, 20, 30 mg/kg, ip) showed a significant (P<0.001) decrease on MORPHINEtolerance. CONCLUSION: It can be concluded that stimulation of adrenergic receptors are at least part of the EPHEDRINE ANTINOCICEPTION, and stimulation of these receptors attenuate TOLERANCE induced to MORPHINE ANTINOCICEPTION.

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APA: Copy

HABIBIASL, B., & SOLTANI, R.. (2005). EFFECT OF EPHEDRINE ON MORPHINE ANTINOCICEPTION AND TOLERANCE INDUCED TO MORPHINE ANTINOCICEPTION IN MICE. PHARMACEUTICAL SCIENCES, -(2), 11-15. SID. https://sid.ir/paper/48711/en

Vancouver: Copy

HABIBIASL B., SOLTANI R.. EFFECT OF EPHEDRINE ON MORPHINE ANTINOCICEPTION AND TOLERANCE INDUCED TO MORPHINE ANTINOCICEPTION IN MICE. PHARMACEUTICAL SCIENCES[Internet]. 2005;-(2):11-15. Available from: https://sid.ir/paper/48711/en

IEEE: Copy

B. HABIBIASL, and R. SOLTANI, “EFFECT OF EPHEDRINE ON MORPHINE ANTINOCICEPTION AND TOLERANCE INDUCED TO MORPHINE ANTINOCICEPTION IN MICE,” PHARMACEUTICAL SCIENCES, vol. -, no. 2, pp. 11–15, 2005, [Online]. Available: https://sid.ir/paper/48711/en

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