CHARACTERIZATION OF BLACTX GENE AND CROSS-RESISTANCE IN KLEBSIELLA PNEUMONIAE ISOLATED FROM HOSPITALIZED PATIENTS

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POURALI SHESHBLOUKI GHOLAMREZA; MARDANEH JALAL

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Journal: Journal of Birjand University of Medical Sciences Year:2016 | Volume:23 | Issue:1 Page(s): 0-0

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Title

CHARACTERIZATION OF BLACTX GENE AND CROSS-RESISTANCE IN KLEBSIELLA PNEUMONIAE ISOLATED FROM HOSPITALIZED PATIENTS

Author(s)

POURALI SHESHBLOUKI GHOLAMREZA | MARDANEH JALAL | Issue Writer Certificate

Keywords

HOSPITALIZED PATIENTS

BLOOD

BACTERIAL INFECTION

KLEBSIELLA PNEUMONIAE

ANTIBIOTIC RESISTANCE PATTERN

SUSCEPTIBLE-DOSE DEPENDENT

Abstract

Background and Aim: KLEBSIELLA PNEUMONIAE is a member of the Enterobacteriaceae family. There is a global emergence of multidrug-resistant (MDR) strains ofK. pneumoniae, a Gram-negative enteric bacterium that causes nosocomial and urinary tract infections. The aims of the present study were to identify theKlebsiella pneumoniae infections in HOSPITALIZED PATIENTS, characterization of bla CTX gene, detection cross-resistance and cefepime SUSCEPTIBLE-DOSE DEPENDENT (SDD) in isolates.Materials and Methods: In present study, 111 strains of KLEBSIELLA PNEUMONIAE were isolated from patients hospitalized in Ghotbadden, Faghihi and Nemazee hospitals (Shiraz, Iran). The isolates were identified as K. pneumoniae, based on biochemical tests embedded in the API-20E system. Susceptibility testing (disc diffusion) was performed according clinical and laboratory standards institute (CLSI) guidelines. Detection cefepime SUSCEPTIBLE-DOSE DEPENDENT (SDD)was performed. The detection of AmpC β - lactamases producing strains was done based on cefoxitin and cefepime disk tests. Thebla CTX gene was detected in the isolates by PCR molecular method.Results: Total 111 KLEBSIELLA PNEUMONIAE isolates were studied. The less effective drug was ceftazidime (37.8% isolates were sensitive). All SDD strains were susceptible to colistin and imipenem. Colistin (96.4%) and imipenem (88.3%) were the most effective antibiotics against isolates. Respectively, 41.4% and 35.1% isolates displayed resistance to gentamicin and amikacin. All colistin resistant isolates were imipenem sensitive. The results of PCR onbla CTX gene showed that 70.3% of the isolates possess the gene.Conclusion: Carbapenem drugs are effective against Klebsieella pneumoniae infections. These results indicate that multidrug-resistant (MDR) and extensively drug resistant (XDR) strains ofK.pneumoniae are rising, and fewer antibiotics may be useful for treating infections caused by these strains. Routine investigation and reporting of antibiotics resistance profile in patients presenting withKlebsiella infections is suggested.

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APA: Copy

POURALI SHESHBLOUKI, GHOLAMREZA, & MARDANEH, JALAL. (2016). CHARACTERIZATION OF BLACTX GENE AND CROSS-RESISTANCE IN KLEBSIELLA PNEUMONIAE ISOLATED FROM HOSPITALIZED PATIENTS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 23(1), 0-0. SID. https://sid.ir/paper/356337/en

Vancouver: Copy

POURALI SHESHBLOUKI GHOLAMREZA, MARDANEH JALAL. CHARACTERIZATION OF BLACTX GENE AND CROSS-RESISTANCE IN KLEBSIELLA PNEUMONIAE ISOLATED FROM HOSPITALIZED PATIENTS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(1):0-0. Available from: https://sid.ir/paper/356337/en

IEEE: Copy

GHOLAMREZA POURALI SHESHBLOUKI, and JALAL MARDANEH, “CHARACTERIZATION OF BLACTX GENE AND CROSS-RESISTANCE IN KLEBSIELLA PNEUMONIAE ISOLATED FROM HOSPITALIZED PATIENTS,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/356337/en

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