COMPARING THE DIAGNOSTIC VALUES OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES AND RHEUMATOID FACTOR FOR RHEUMATOID ARTHRITIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HEYDARI BEHZAD; LOTFI ZAHRA; FIROUZJAHI A.R.; HEYDARI P.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Research in Medicine Year:2009 | Volume:33 | Issue:3 Page(s): 148-155

Download Full-Text

Persian Verion

View:

1,214

Download:

Cites:

Information Journal Paper

Title

COMPARING THE DIAGNOSTIC VALUES OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES AND RHEUMATOID FACTOR FOR RHEUMATOID ARTHRITIS

Author(s)

HEYDARI BEHZAD | LOTFI ZAHRA | FIROUZJAHI A.R. | HEYDARI P. | Issue Writer Certificate

Keywords

RHEUMATOID ARTHRITISQ2

ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODYQ3

DIAGNOSTIC VALUEQ3

RHEUMATOID FACTORQ3

Abstract

Background: RHEUMATOID ARTHRITIS, (RA) is a chronic inflammatory autoimmune disease with a progressive course requiring early diagnosis and treatment. The value of anti-cyclic citrullinated peptide antibodies (Anti-CCP) in the diagnosis of RA has been shown in several studies. The present study was designed to determine and compare the DIAGNOSTIC VALUE of Anti-CCP and RHEUMATOID FACTOR (RF) for RA.Methods: 207 females and 48 males with RA, diagnosed by clinical criteria, with the mean age of 50±13.8 years and 290 non-RA controls with the mean age of 47±14 years were enrolled in the study. Serum samples were taken for assessment of Anti-CCP and RF from all participants.Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-)and their 95% confidence interval (95%CI) were estimated by comparison of patients with controls. Results: In patients with RA, Anti-CCP was positive in 79.2% and RF was positive in 72.1%; and both antibodies were positive in 64.7%, and both negative in 13.3%. 47.8% of seronegative RA was Anti-CCP positive and 7.8% of anti-CCP negative were RF positive.Sensitivity, specificity, PPV, NPV, LR+ and LR- for Anti-CCP in diagnosis of RA were: 79.2%, 94.8%. 93.08%, 83.8%, 13.46 and 0.19 respectively; for RF the respective values were 72.1%, 90.6%, 87.2 %, 78.7%, 6.81, and 0.26. For both Anti-CCP and RF the values were 64.7%, 97.5%, 95.9 %, 75.8%, 26.8and 0.36.Anti-CCP was more diagnostic than RF and both antibodies had more DIAGNOSTIC VALUEs than either of them alone. Anti-CCP yielded a specificity of 89.6% and PPV of 85% for diagnosis of seronegative RA.Conclusion: The findings of this study indicate that anti-CCP has a higher diagnostic performance than RF. It is highly useful in the diagnosis of seronegative RA. In addition, presence of both antibodies is more diagnostic than either of them alone.

Cites

No record.

References

No record.

Cite

APA: Copy

HEYDARI, BEHZAD, LOTFI, ZAHRA, FIROUZJAHI, A.R., & HEYDARI, P.. (2009). COMPARING THE DIAGNOSTIC VALUES OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES AND RHEUMATOID FACTOR FOR RHEUMATOID ARTHRITIS. PAJOUHESH DAR PEZESHKI, 33(3), 148-155. SID. https://sid.ir/paper/356777/en

Vancouver: Copy

HEYDARI BEHZAD, LOTFI ZAHRA, FIROUZJAHI A.R., HEYDARI P.. COMPARING THE DIAGNOSTIC VALUES OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES AND RHEUMATOID FACTOR FOR RHEUMATOID ARTHRITIS. PAJOUHESH DAR PEZESHKI[Internet]. 2009;33(3):148-155. Available from: https://sid.ir/paper/356777/en

IEEE: Copy

BEHZAD HEYDARI, ZAHRA LOTFI, A.R. FIROUZJAHI, and P. HEYDARI, “COMPARING THE DIAGNOSTIC VALUES OF ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES AND RHEUMATOID FACTOR FOR RHEUMATOID ARTHRITIS,” PAJOUHESH DAR PEZESHKI, vol. 33, no. 3, pp. 148–155, 2009, [Online]. Available: https://sid.ir/paper/356777/en

Related Journal Papers