The effect of 4 weeks of aerobic activity on the ratio of Serum levels of tumor necrosis factor alpha, interleukin-10 and brain-derived neurotrophic factor in C57 rat brain tissue by induction of experimental autoimmune encephalomyelitis (EAE)

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VATANDOUST MARYAM; Seyed Alhosseini Seyed Mehdi; Nasirzadeh Abdolmahdi; Jourabloo Azam

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:7 Page(s): 624-645

Download Full-Text

Persian Verion

View:

457

Download:

Cites:

Information Journal Paper

Title

The effect of 4 weeks of aerobic activity on the ratio of Serum levels of tumor necrosis factor alpha, interleukin-10 and brain-derived neurotrophic factor in C57 rat brain tissue by induction of experimental autoimmune encephalomyelitis (EAE)

Author(s)

VATANDOUST MARYAM | Seyed Alhosseini Seyed Mehdi | Nasirzadeh Abdolmahdi | Jourabloo Azam | Issue Writer Certificate

Keywords

Aerobic ActivityQ2

Tumor necrosis factor alphaQ1

Interleukin 10Q2

Brain-derived neurotrophic factorQ2

Multiple sclerosisQ2

Abstract

Introdution: According to importance of complimentary therapies. This study was conducted to investigate the effect of a four-week aerobic physical activities in water on the extent of clinical improvement and amount of Tumor necrosis factor alpha, TNF-α , Interleukin 10, IL-10 on serum levels and Brain-derived neurotrophic factor in the brain tissue of the animal model of of Multiple sclerosis (MS) via inducing experimental autoimmune encephalomyelitis (EAE). Methods: In this experimental study, a total number of 80 female Syrian mice from the race of C57BL/6, , aging 10 to 12 weeks and weighing 20 ± 2 gram were divided into eight groups of 10, namely, control, swimming, MS, MS + swimming, MS + interferon beta (INF-β ), MS + interferon beta + swimming, MS + solvent, and MS + solvent + swimming environment. For induction of EAE, 300 μ g (35-55) myelin oligodendrocyte glycoprotein (MOG) was first mixed in 100 μ l phosphate buffered saline (PBS) with complete Freund's adjuvant (CFA) and injected subcutaneously (SC). At the time of injection and after 48 hours, 300 ng pertussis toxin was diluted in PBS and injected intraperitoneally (IP). During a week after the treatment, mice receiving were the drug in form intraperitoneal received 150 IU/g of the drug per day. Clinical symptoms and the mice's weights were recorded every day. Physical activity group did the aerobic activities for four weeks, five sessions a week, 30 minutes each session. Finally Brains were extracted and blood samples were taken from the heart and enzyme-linked immunosorbent assay (ELISA) was applied to measure markers. Data analysis was done using one-way ANOVA. Results: Based on the findings of this study, physical activity compared to interferon beta-1 treatment significantly increased the BDNF factor in mice, increased IL-10, and decreased TNF-α in serum. Conclusion: Aerobic swimming exercises could most probably help remyelination by regulation of inflammatory factors and lowering the speed of myelin destruction, hence, helping the clinical improvement in patients with Multiple sclerosis.

Cites

No record.

References

No record.

Cite

APA: Copy

VATANDOUST, MARYAM, Seyed Alhosseini, Seyed Mehdi, Nasirzadeh, Abdolmahdi, & Jourabloo, Azam. (2018). The effect of 4 weeks of aerobic activity on the ratio of Serum levels of tumor necrosis factor alpha, interleukin-10 and brain-derived neurotrophic factor in C57 rat brain tissue by induction of experimental autoimmune encephalomyelitis (EAE). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(7 ), 624-645. SID. https://sid.ir/paper/35707/en

Vancouver: Copy

VATANDOUST MARYAM, Seyed Alhosseini Seyed Mehdi, Nasirzadeh Abdolmahdi, Jourabloo Azam. The effect of 4 weeks of aerobic activity on the ratio of Serum levels of tumor necrosis factor alpha, interleukin-10 and brain-derived neurotrophic factor in C57 rat brain tissue by induction of experimental autoimmune encephalomyelitis (EAE). JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(7 ):624-645. Available from: https://sid.ir/paper/35707/en

IEEE: Copy

MARYAM VATANDOUST, Seyed Mehdi Seyed Alhosseini, Abdolmahdi Nasirzadeh, and Azam Jourabloo, “The effect of 4 weeks of aerobic activity on the ratio of Serum levels of tumor necrosis factor alpha, interleukin-10 and brain-derived neurotrophic factor in C57 rat brain tissue by induction of experimental autoimmune encephalomyelitis (EAE),” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 7 , pp. 624–645, 2018, [Online]. Available: https://sid.ir/paper/35707/en

Related Journal Papers