EVALUATION OF THREE DIFFERENT ADMINISTRATION ROUTES (IM, SC AND IN) ON HUMORAL IMMUNE RESPONSES AGAINST MYCOBACTERIUM TUBERCULOSIS ESAT-6/CFP-10 FUSION PROTEIN

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NAMVARPOUR MOJDEH; MANSOURI REZA; TEBIANIAN MAJID

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:7 Page(s): 537-546

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Title

EVALUATION OF THREE DIFFERENT ADMINISTRATION ROUTES (IM, SC AND IN) ON HUMORAL IMMUNE RESPONSES AGAINST MYCOBACTERIUM TUBERCULOSIS ESAT-6/CFP-10 FUSION PROTEIN

Author(s)

NAMVARPOUR MOJDEH | MANSOURI REZA | TEBIANIAN MAJID | Issue Writer Certificate

Keywords

MYCOBACTERIUM TUBERCULOSISQ2

INTRAMUSCULAR INJECTIONQ3

SUBCUTANEOUS INJECTIONQ3

INTRANASAL ADMINISTRATIONQ1

ESAT-6/CFP-10Q1

Abstract

Introduction: Tuberculosis (TB) has been considered as a main health problems of the present century.Unfortunately, it has been reported different protective responses against BCG vaccine, as only available vaccine against TB. The search for a new and improved vaccine against tuberculosis is currently a very active field of research. In this study, we have evaluated the relative effects of intranasal (i.n), subcutaneous (s.c) and intramuscular (i.m) routes of immunization on the induction of humoral immune responses against TB recombinant protein.Methods: The recombinant ESAT-6/CFP-10 antigens has been assessed and confirmed preliminary, for this study. The Balb/C mice were immunized in 3 different routes, three times at 2-week intervals with recombinant protein, formulated with or without adjuvants (MF-59 for the i.m and s.c routes and CTB for i.n). Blood was collected from retro-orbital sinus 10 days after each immunization and after separation of sera, they were evaluated for specific antibodies against antigen by an indirect ELISA method, which had set up during the research.Results: Mice vaccinated against recombinant proteins had high level of specific antibodies compared to the controls. Our results showed that although the i.m and s.c injections also induce immune responses, but the antibody titer in i.n rout had graduately elevated to reach in acceptable levels.Conclusion: The results could be used for formulation of mucosal vaccines against tuberculosis in future studies.

Cites

بررسی میزان بیان سرمی miR-21 در بیماران مشکوک به عفونت مایکوباکتریوم توبرکلوزیس

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APA: Copy

NAMVARPOUR, MOJDEH, MANSOURI, REZA, & TEBIANIAN, MAJID. (2017). EVALUATION OF THREE DIFFERENT ADMINISTRATION ROUTES (IM, SC AND IN) ON HUMORAL IMMUNE RESPONSES AGAINST MYCOBACTERIUM TUBERCULOSIS ESAT-6/CFP-10 FUSION PROTEIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(7 ), 537-546. SID. https://sid.ir/paper/35751/en

Vancouver: Copy

NAMVARPOUR MOJDEH, MANSOURI REZA, TEBIANIAN MAJID. EVALUATION OF THREE DIFFERENT ADMINISTRATION ROUTES (IM, SC AND IN) ON HUMORAL IMMUNE RESPONSES AGAINST MYCOBACTERIUM TUBERCULOSIS ESAT-6/CFP-10 FUSION PROTEIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(7 ):537-546. Available from: https://sid.ir/paper/35751/en

IEEE: Copy

MOJDEH NAMVARPOUR, REZA MANSOURI, and MAJID TEBIANIAN, “EVALUATION OF THREE DIFFERENT ADMINISTRATION ROUTES (IM, SC AND IN) ON HUMORAL IMMUNE RESPONSES AGAINST MYCOBACTERIUM TUBERCULOSIS ESAT-6/CFP-10 FUSION PROTEIN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 7 , pp. 537–546, 2017, [Online]. Available: https://sid.ir/paper/35751/en

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