COMPARISON OF SPERM PLCζ PROTEIN AND DNA DAMAGE BETWEEN FERTILE AND INFERTILE MEN

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TAVALAEE MARZIYEH; ARBABIAN MARYAM; NASR ESFAHANI MOHAMMAD HOSSEIN

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Title

COMPARISON OF SPERM PLCζ PROTEIN AND DNA DAMAGE BETWEEN FERTILE AND INFERTILE MEN

Author(s)

TAVALAEE MARZIYEH | ARBABIAN MARYAM | NASR ESFAHANI MOHAMMAD HOSSEIN | Issue Writer Certificate

Keywords

PLCζQ1

ICSIQ3

DNA DAMAGEQ1

SPERM PARAMETERSQ2

Abstract

Introduction: Sperm-specific phospholipase C zeta (PLCz) protein is expressed during spermatogenesis and plays a main role during oocyte activation. In this study, the expression of sperm PLCz protein and DNA DAMAGE in fertile and infertile men was assessed.Methods: In this case-control study, semen samples were collected from 15 fertile and 10 infertile men candidated for intra-cytoplasmic sperm injection (ICSI). SPERM PARAMETERS, the expression of PLCz protein, and DNA DAMAGE were assessed by the World Health Organization (2010) protocol, Western Blot, and TUNEL assay, respectively.Results: The quality of SPERM PARAMETERS were significantly lower in the infertile men compared with the fertile men. In addition, the expression of PLCz protein was significantly lower, and percentage of sperm DNA DAMAGE were significantly higher in infertile men than fertile men.Conclusion: Our results clearly showed that low or absence expression of PLCz and sperm DNA DAMAGE could be considered as factors involved in failed fertilization in these infertile men. Therefore, the evaluation of some tests such as PLCz protein and chromatin tests to assess fertilization potential of a semen sample for infertile men are recommended.

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APA: Copy

TAVALAEE, MARZIYEH, ARBABIAN, MARYAM, & NASR ESFAHANI, MOHAMMAD HOSSEIN. (2017). COMPARISON OF SPERM PLCζ PROTEIN AND DNA DAMAGE BETWEEN FERTILE AND INFERTILE MEN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(7 ), 585-594. SID. https://sid.ir/paper/35755/en

Vancouver: Copy

TAVALAEE MARZIYEH, ARBABIAN MARYAM, NASR ESFAHANI MOHAMMAD HOSSEIN. COMPARISON OF SPERM PLCζ PROTEIN AND DNA DAMAGE BETWEEN FERTILE AND INFERTILE MEN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(7 ):585-594. Available from: https://sid.ir/paper/35755/en

IEEE: Copy

MARZIYEH TAVALAEE, MARYAM ARBABIAN, and MOHAMMAD HOSSEIN NASR ESFAHANI, “COMPARISON OF SPERM PLCζ PROTEIN AND DNA DAMAGE BETWEEN FERTILE AND INFERTILE MEN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 7 , pp. 585–594, 2017, [Online]. Available: https://sid.ir/paper/35755/en

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