HEMOLYTIC UREMIC SYNDROME IN CHILDREN SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, 1988-98

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DERAKHSHAN A.; MOHKAM M.

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Journal: Researcher Bulletin of Medical Sciences Year:2002 | Volume:7 | Issue:2 (28) Page(s): 171-174

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Title

HEMOLYTIC UREMIC SYNDROME IN CHILDREN SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, 1988-98

Author(s)

DERAKHSHAN A. | MOHKAM M. | Issue Writer Certificate

Keywords

HEMOLYTIC UREMIC SYNDROMEQ4

ACUTE RENAL FAILUREQ3

CLINICAL JEATURES. COMPLICATIONQ3

CHILDRENQ3

Abstract

Background: HEMOLYTIC UREMIC SYNDROME (HUS) is known as the most common cause of ACUTE RENAL FAILURE in neonates and young CHILDREN. We have studied the prevalence and clinical features of HEMOLYTIC UREMIC SYNDROME for a ten-year period (1988-99) in Shiraz University of Medical Sciences. Materials and methods: Reports of 80 CHILDREN hospitalized due to HUS were reviewed. Initial data including clinical features, laboratory findings, treatment, complications and prognosis of disease were determined. Results: CHILDREN were aged 3 months to 14 years (mean, 2.29±2.38 years). They included 45 boys and 35 girls. 74 developed the classic fOffi1 of HUS (with diarrhea) and the remaining 6 had presented non-classic form of HUS. The most common signs were pallor (100%), oliguria or anuria (70%), altered level of consciousness (35%), and seizure (24%). Other clinical or laboratory findings were: petechia and purpura (11%), jaundice (4%), hypertension (16%), anemia (100%), elevated BUN and creatinine (100%), thrombocytopenia (87.5%), leukocytosis (59%), hyponatremia (52.5%), hypokalemia (65%), hyperkalemia (14%), hypoalbuminemia (70%), and elevated LFT (14%). The entire CHILDREN had received FFP (1-14 times) and 70% had been dialyzed for a mean 6.4 days. Colonoscopy of 6 CHILDREN with prolonged diarrhea had revealed pseudomembranous colitis. The overall mortality rate was 15%. Mortality was mainly correlated with prolonged diarrhea, anuria or oliguria, and dialysis. Conclusion: HEMOLYTIC UREMIC SYNDROME (HUS) is a problem of utmost importance in pediatric disease that could lead to irreversible changes. This requires further attention.

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APA: Copy

DERAKHSHAN, A., & MOHKAM, M.. (2002). HEMOLYTIC UREMIC SYNDROME IN CHILDREN SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, 1988-98. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), 7(2 (28)), 171-174. SID. https://sid.ir/paper/357704/en

Vancouver: Copy

DERAKHSHAN A., MOHKAM M.. HEMOLYTIC UREMIC SYNDROME IN CHILDREN SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, 1988-98. RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH)[Internet]. 2002;7(2 (28)):171-174. Available from: https://sid.ir/paper/357704/en

IEEE: Copy

A. DERAKHSHAN, and M. MOHKAM, “HEMOLYTIC UREMIC SYNDROME IN CHILDREN SHIRAZ UNIVERSITY OF MEDICAL SCIENCES, 1988-98,” RESEARCHER BULLETIN OF MEDICAL SCIENCES (PEJOUHANDEH), vol. 7, no. 2 (28), pp. 171–174, 2002, [Online]. Available: https://sid.ir/paper/357704/en

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