THE EFFECT OF LOWERING PLASMA TRIGLYCERIDES WITH CLOFIBRATE ON GLUCOSE CONTROL IN PATIENTS WITH NIDDM AND HYPERTRIGLYCERIDEMIA

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SOVEID M.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2000 | Volume:8 | Issue:2 Page(s): 78-82

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Information Journal Paper

Title

THE EFFECT OF LOWERING PLASMA TRIGLYCERIDES WITH CLOFIBRATE ON GLUCOSE CONTROL IN PATIENTS WITH NIDDM AND HYPERTRIGLYCERIDEMIA

Author(s)

SOVEID M. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

HYPERTRIGLYCERIDEMIAQ3

CLOFIBRATEQ3

BLOOD GLUCOSEQ2

Abstract

It has been suggested that disorders of lipid metabolism has an important role in pathogenesis of NIDDM. The high level of free fatty acid in NIDDM can prevent glucose uptake by peripheral tissues and may cause insulin resistance. Fibric acids, including CLOFIBRATE has been shown to decrease the level of free fatty acid, thus it may decrease insulin resistance. The goal of this study was to investigate whether treatment of hypotriglyceridemia with CLOFIBRATE improves glucose control in NIDDM or not. 30 NIDDM patients with triglyceride level above 250 mg/dl were enrolled in this study. The characteristics of patients were as follow: mean age: 52.5 ±7.8 yrs, mean BMI: 27/6 ±3.3 kg/m2, mean FBS: 217.5±49.3 mg/dl, and mean 2hpp: 295.9±71.9 mg/dl, mean Hb A1C: 105±1.2%, mean TG: 466.5±155 mg/dl and mean cholesterol: 252.0±38.1 mg/dl. The patients were given CLOFIBRATE 1500 mg/day for 10 weeks and the above parameters were measured again. The oral hypoglycemic agent dosage and diet were not changed during study. The level of all the above parameters were decreased with administration of CLOFIBRATE as follow (P<0.0001): FBS: 178.9±54, 21 PP: 233.5±56, TG: 227.4±54, Chol: 226.9±27, HbA1C: 9.0±1.2%. It was concluded that CLOFIBRATE treatment of HYPERTRIGLYCERIDEMIA in NIDDM patients can improve glucose control.

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APA: Copy

SOVEID, M.. (2000). THE EFFECT OF LOWERING PLASMA TRIGLYCERIDES WITH CLOFIBRATE ON GLUCOSE CONTROL IN PATIENTS WITH NIDDM AND HYPERTRIGLYCERIDEMIA. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 8(2), 78-82. SID. https://sid.ir/paper/35775/en

Vancouver: Copy

SOVEID M.. THE EFFECT OF LOWERING PLASMA TRIGLYCERIDES WITH CLOFIBRATE ON GLUCOSE CONTROL IN PATIENTS WITH NIDDM AND HYPERTRIGLYCERIDEMIA. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;8(2):78-82. Available from: https://sid.ir/paper/35775/en

IEEE: Copy

M. SOVEID, “THE EFFECT OF LOWERING PLASMA TRIGLYCERIDES WITH CLOFIBRATE ON GLUCOSE CONTROL IN PATIENTS WITH NIDDM AND HYPERTRIGLYCERIDEMIA,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 2, pp. 78–82, 2000, [Online]. Available: https://sid.ir/paper/35775/en

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