Preventive effect of injections of vitamin D on the levels of Klotho in the brain tissue of female lewis rats with experimental autoimmune ensephalomyelitis

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Fatemi Seyedeh Fatemeh; FALLAH MOHAMMADI ZIYA; Talebi Vahid; Hosseini Sayed Mojtaba

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:8 Page(s): 662-670

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Title

Preventive effect of injections of vitamin D on the levels of Klotho in the brain tissue of female lewis rats with experimental autoimmune ensephalomyelitis

Author(s)

Fatemi Seyedeh Fatemeh | FALLAH MOHAMMADI ZIYA | Talebi Vahid | Hosseini Sayed Mojtaba | Issue Writer Certificate

Keywords

Experimental autoimmune encephalomyelitisQ2

Vitamin DQ1

KlothoQ3

Abstract

Introdution: The aim of this study was to investigate the effect of Vitamin D supplementation on Klotho levels of the brain tissue. Methods: In this laboratory experimental study, 25 female Lewis rats, after 2 weeks adaptation to lab environmental, were randomly divided into 5 groups: 1-control; 2-control+ EAE; 3-sham; 4-Vitamin D; 5-vitaminD + EAE. Results: The data were analyzed using one way ANOVA, and to examine the weight changes Mann-Whitney test was used to the research groups. In order to induce EAE, 0. 4 ml of solution, a combination of guinea Hindi pig spinal cord and adjuvant ratio was injected to each animal. Klotho levels were measured by ELISA. Finding: There was significantly different in Klotho levels of brain tissue of control+ EAE compared to control group (P=0/001). There was significant difference in Klotho levels of the brain tissue in EAE +Vitamin D group compared to control group (P=0/001). In addition, the weight of Vitamin D+EAE group was more than control+EAE group (P=0/006). Conclusion: Pre-treatment with Vitamin D supplementation increases the Klotho levels of brain tissue and may have protective role against EAE.

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APA: Copy

Fatemi, Seyedeh Fatemeh, FALLAH MOHAMMADI, ZIYA, Talebi, Vahid, & Hosseini, Sayed Mojtaba. (2018). Preventive effect of injections of vitamin D on the levels of Klotho in the brain tissue of female lewis rats with experimental autoimmune ensephalomyelitis. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(8 ), 662-670. SID. https://sid.ir/paper/35787/en

Vancouver: Copy

Fatemi Seyedeh Fatemeh, FALLAH MOHAMMADI ZIYA, Talebi Vahid, Hosseini Sayed Mojtaba. Preventive effect of injections of vitamin D on the levels of Klotho in the brain tissue of female lewis rats with experimental autoimmune ensephalomyelitis. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(8 ):662-670. Available from: https://sid.ir/paper/35787/en

IEEE: Copy

Seyedeh Fatemeh Fatemi, ZIYA FALLAH MOHAMMADI, Vahid Talebi, and Sayed Mojtaba Hosseini, “Preventive effect of injections of vitamin D on the levels of Klotho in the brain tissue of female lewis rats with experimental autoimmune ensephalomyelitis,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 8 , pp. 662–670, 2018, [Online]. Available: https://sid.ir/paper/35787/en

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