The effect of vitamin D supplementation on plasma levels of anti-aging protein Klotho in elderly

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Jebreal Azimzadeh Maryam; SHIDFAR FARZAD; JAZAYERI SHIMA; HOSSEINI AGHA FATEMEH

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Journal: Razi Journal of Medical Sciences Year:2018 | Volume:25 | Issue:9 Page(s): 83-92

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Title

The effect of vitamin D supplementation on plasma levels of anti-aging protein Klotho in elderly

Author(s)

Jebreal Azimzadeh Maryam | SHIDFAR FARZAD | JAZAYERI SHIMA | HOSSEINI AGHA FATEMEH | Issue Writer Certificate

Keywords

Vitamin DQ2

Klotho proteinQ1

ElderlyQ2

Abstract

Background: The percentage of Elderly people is growing in our country. Aging is associated with multiple diseases, disabilities and heavy medical expenses. The new multifunctionalProtein, Klotho, not only reduces the aging process but also affects several diseases associated with older ages. The aim of this study was to evaluate the effect of Vitamin D supplements on the plasma levels of klotho in the Elderly. Methods: This study was conducted in a randomized clinical trial in 81 Elderly, with insufficient Vitamin D plasma levels (10-30 ng/ml) for 12 weeks. Individuals randomly divided into two groups of Vitamin D supplements (50000 IU) and placebo once a week. Vitamin D was measured by chemiluminescence method and klotho by ELISA. Data was analyzed by SPSS (version 22) software at meaningful level of P <0. 05. Results: 25(OH)D levels were increased and decreased significantly in Vitamin D and placebo group respectively (p<0. 001 & p<0. 001 respectively), and its changes between the two groups was significantly different at the end of the intervention (p<0. 001). The mean Klotho protein levels and its changes after the intervention were significantly different between the two groups (p=0. 014 & p<0. 001 respectively). The mean Klotho protein levels in the Vitamin D group was not change significantly (p=0. 164). Conclusion: The findings of this study showed, weekly intake of 50, 000 IU Vitamin D for 12 weeks in Elderly peoplewith insufficient Vitamin D levels, caused significant difference in Klotho protein and Vitamin D changes between the two groups, and also Vitamin D levels in Vitamin D group was increased significantly at the end of the intervention.

Cites

References

Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial

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APA: Copy

Jebreal Azimzadeh, Maryam, SHIDFAR, FARZAD, JAZAYERI, SHIMA, & HOSSEINI, AGHA FATEMEH. (2018). The effect of vitamin D supplementation on plasma levels of anti-aging protein Klotho in elderly. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 25(9 ), 83-92. SID. https://sid.ir/paper/10953/en

Vancouver: Copy

Jebreal Azimzadeh Maryam, SHIDFAR FARZAD, JAZAYERI SHIMA, HOSSEINI AGHA FATEMEH. The effect of vitamin D supplementation on plasma levels of anti-aging protein Klotho in elderly. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2018;25(9 ):83-92. Available from: https://sid.ir/paper/10953/en

IEEE: Copy

Maryam Jebreal Azimzadeh, FARZAD SHIDFAR, SHIMA JAZAYERI, and AGHA FATEMEH HOSSEINI, “The effect of vitamin D supplementation on plasma levels of anti-aging protein Klotho in elderly,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 25, no. 9 , pp. 83–92, 2018, [Online]. Available: https://sid.ir/paper/10953/en

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