SYNTHESIS AND ANTICONVULSANY EFFECTS OF 2-(2-ALKYLTHIO-1- BENZYL-S- IMIDAZOLYL) -2,3,4- TRIHYDRO- 1,3,4-THIADIAZOLES IN MICE

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HADIZADEH F.; HOSSEINZADEH H.; KALANTARI M.; KIASAT R.; MEHRABI M.

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Journal: Iranian Journal of Basic Medical Sciences Year:2003 | Volume:6 | Issue:2 (18) Page(s): 168-174

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Title

SYNTHESIS AND ANTICONVULSANY EFFECTS OF 2-(2-ALKYLTHIO-1- BENZYL-S- IMIDAZOLYL) -2,3,4- TRIHYDRO- 1,3,4-THIADIAZOLES IN MICE

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Keywords

NON-BENZODIAZEPINE LIGANDSQ4

BENZODIAZEPINE RECEPTORSQ4

IMIDAZOLEQ3

Abstract

Starting from 1-benzyl-2- mercapto-5-hydroymethylimidazole which is prepared readily, a series of novel 2-(2-alkylthio-l-benzyl-5-imidazolyl) -2,3,4- trihydro-5- imino- 1,3,4- thiadiazoles [4a-c] were synthesized through multiple steps. The anticonvulsant activities of the title compounds [4a-c] were studied id mice in order to identify more potent anticonvulsant agents. In maximum electroshock test except 4a other compounds [4b,c] decreased the duration of tonic seizures. These results indicate that they may have beneficial effects in grand mal seizures, but their potency, compared with diazepam was very lower.

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APA: Copy

HADIZADEH, F., HOSSEINZADEH, H., KALANTARI, M., KIASAT, R., & MEHRABI, M.. (2003). SYNTHESIS AND ANTICONVULSANY EFFECTS OF 2-(2-ALKYLTHIO-1- BENZYL-S- IMIDAZOLYL) -2,3,4- TRIHYDRO- 1,3,4-THIADIAZOLES IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 6(2 (18)), 168-174. SID. https://sid.ir/paper/357895/en

Vancouver: Copy

HADIZADEH F., HOSSEINZADEH H., KALANTARI M., KIASAT R., MEHRABI M.. SYNTHESIS AND ANTICONVULSANY EFFECTS OF 2-(2-ALKYLTHIO-1- BENZYL-S- IMIDAZOLYL) -2,3,4- TRIHYDRO- 1,3,4-THIADIAZOLES IN MICE. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2003;6(2 (18)):168-174. Available from: https://sid.ir/paper/357895/en

IEEE: Copy

F. HADIZADEH, H. HOSSEINZADEH, M. KALANTARI, R. KIASAT, and M. MEHRABI, “SYNTHESIS AND ANTICONVULSANY EFFECTS OF 2-(2-ALKYLTHIO-1- BENZYL-S- IMIDAZOLYL) -2,3,4- TRIHYDRO- 1,3,4-THIADIAZOLES IN MICE,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 6, no. 2 (18), pp. 168–174, 2003, [Online]. Available: https://sid.ir/paper/357895/en

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