STUDY OF ANALGESIC EFFECT OF HYDROALCOHOLIC EXTRACT OF CINAMMOM

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ARZI A.; SARKAKI A.; AGHEL N.; NAZARI Z.; SAEIDNEJAD S.

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Journal: Jundishapur Scientific Medical Journal Year:2011 | Volume:10 | Issue:3 (72) Page(s): 272-279

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Title

STUDY OF ANALGESIC EFFECT OF HYDROALCOHOLIC EXTRACT OF CINAMMOM

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Keywords

CINNAMOMUM ZEYLANICUMQ2

PAINQ2

FORMALIN TESTQ2

ASPIRINQ2

MORPHINEQ3

RATQ2

Abstract

Background and Objective: The side effects due to application of synthetic analgesic drugs in the clinical practice have turned on researchers to focus on development of herbal medicine as more appropriate analgesic agents. The aim of this study was evaluation the analgesic effects of hydroalcholic extract of CINNAMOMUM ZEYLANICUMin comparison with MORPHINE and ASPIRIN.Materiales and Methods: For preparing the hydroalcoholic extract of Cinnamomum the maceration method was used. Wistar male RATs were divided into eight groups of 6 RATs, randomly and treated groups have received 200, 400, 600, 800 mg/kg extract and the two positive control groups received 2.5 mg/kg MORPHINE or 300 mg/kg ASPIRIN. Negative control group received normal saline (5ml/kg) and an additional group also received 600 mg/kg extract+1 mg/kg naloxan intraperitonealy respectively. 50 ml formalin 2.5% was injected in right hindpaw subcutaneously and analgesic behaviors were scored.Results: The results revealed that the CINNAMOMUM ZEYLANICUM extract had analgesic effect as dose-dependent and its analgesic effective dose was 600 mg/kg. Our results showed that the analgesic effect of its best effective dose (600 mg/kg) on acute PAIN was more than ASPIRIN while it was less than MORPHINE. Also the effect of extract on chronic PAIN was less than MORPHINE and ASPIRIN. There were no significant differences between analgesic effects of CINNAMOMUM ZEYLANICUM extract with naloxone or alone.Conclusion: We concluded that the analgesic effect of CINNAMOMUM ZEYLANICUM extract is dose-dependent and is driven negatively through opioid receptors.

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اثر عصاره هیدروالکلی دارچین بر تشنج القا شده توسط استریکنین در موش سوری

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APA: Copy

ARZI, A., SARKAKI, A., AGHEL, N., NAZARI, Z., & SAEIDNEJAD, S.. (2011). STUDY OF ANALGESIC EFFECT OF HYDROALCOHOLIC EXTRACT OF CINAMMOM. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 10(3 (72)), 272-279. SID. https://sid.ir/paper/358423/en

Vancouver: Copy

ARZI A., SARKAKI A., AGHEL N., NAZARI Z., SAEIDNEJAD S.. STUDY OF ANALGESIC EFFECT OF HYDROALCOHOLIC EXTRACT OF CINAMMOM. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2011;10(3 (72)):272-279. Available from: https://sid.ir/paper/358423/en

IEEE: Copy

A. ARZI, A. SARKAKI, N. AGHEL, Z. NAZARI, and S. SAEIDNEJAD, “STUDY OF ANALGESIC EFFECT OF HYDROALCOHOLIC EXTRACT OF CINAMMOM,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 10, no. 3 (72), pp. 272–279, 2011, [Online]. Available: https://sid.ir/paper/358423/en

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