INTERACTION OF ELECTROMAGNETIC FIELD AND MODULATION OF GABA-B RECEPTOR ON SERUM TESTOSTERONE CONCENTRATION IN AGGRESSIVE RATS

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KARIMI S.; TAHERIANFARD M.; BAHAODDINI A.; FAZELI M.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2011 | Volume:19 | Issue:4 (79) Page(s): 533-541

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Title

INTERACTION OF ELECTROMAGNETIC FIELD AND MODULATION OF GABA-B RECEPTOR ON SERUM TESTOSTERONE CONCENTRATION IN AGGRESSIVE RATS

Author(s)

KARIMI S. | TAHERIANFARD M. | BAHAODDINI A. | FAZELI M. | Issue Writer Certificate

Keywords

ELECTROMAGNETIC PHENOMENAQ2

ADVERSE EFFECTSQ2

BACLOFENQ3

RECEPTORSQ2

GABA-BQ2

AGGRESSIONQ2

PHISIOLOGYQ2

MICEQ2

TESTOSTERONEQ2

Abstract

Introduction: The aim of the present study is to investigate the effect of interaperitoneal injection of BACLOFEN (GABA-B agonist) and CGP35348 (GABA-B antagonist) on serum TESTOSTERONE concentration in aggressive rats exposed to electromagnetic field.Methods: Fifty five mature male rats weighing 200±20 grams were studied. Animals were divided into 2 main groups and four subgroups. Main groups composed of rats with and without exposure to electromagnetic field. Animals in the former group were exposed to electromagnetic field with 500 m T intensity and 50Hz frequency for 8 hours a day for 30 days. AGGRESSION was induced by applying 2mA current every 3 seconds for 5 minutes. Then serum TESTOSTERONE concentration was measured by radioimmunoassay method.Results: Data showed that BACLOFEN injection at 3mg/kg and CGP35348 at 100mg/kg significantly increased serum TESTOSTERONE concentration in aggressive rats exposed to electromagnetic field.Conclusion: According to the simillar effect of BACLOFEN and CGP35348 on TESTOSTERONE secretion, it seems that GABA-B RECEPTORS in testes are two types, so it has caused similar effects. Also, electromagnetic exposure leads to increase in TESTOSTERONE secretion.

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APA: Copy

KARIMI, S., TAHERIANFARD, M., BAHAODDINI, A., & FAZELI, M.. (2011). INTERACTION OF ELECTROMAGNETIC FIELD AND MODULATION OF GABA-B RECEPTOR ON SERUM TESTOSTERONE CONCENTRATION IN AGGRESSIVE RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 19(4 (79)), 533-541. SID. https://sid.ir/paper/35848/en

Vancouver: Copy

KARIMI S., TAHERIANFARD M., BAHAODDINI A., FAZELI M.. INTERACTION OF ELECTROMAGNETIC FIELD AND MODULATION OF GABA-B RECEPTOR ON SERUM TESTOSTERONE CONCENTRATION IN AGGRESSIVE RATS. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;19(4 (79)):533-541. Available from: https://sid.ir/paper/35848/en

IEEE: Copy

S. KARIMI, M. TAHERIANFARD, A. BAHAODDINI, and M. FAZELI, “INTERACTION OF ELECTROMAGNETIC FIELD AND MODULATION OF GABA-B RECEPTOR ON SERUM TESTOSTERONE CONCENTRATION IN AGGRESSIVE RATS,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 4 (79), pp. 533–541, 2011, [Online]. Available: https://sid.ir/paper/35848/en

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