STUDYING ASSOCIATION 48 BP POLYMORPHISM OF DRD4 GENE WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER IN CHILDREN FROM NORTH WEST OF IRAN

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HOSSEINPOUREFEIZI MOHAMMADALI; MEHDIZADEH FANID LEILA; Noorazar Seyed Gholamreza; ADAMPOUREZARE MINA; GHOLIPOUR FALAHI MOHAMMADREZA

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:5 Page(s): 396-403

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Title

STUDYING ASSOCIATION 48 BP POLYMORPHISM OF DRD4 GENE WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER IN CHILDREN FROM NORTH WEST OF IRAN

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Keywords

ADHDQ2

DRD4 GENEQ1

POLYMORPHISMQ2

MOLECULAR MARKERQ1

Abstract

Introduction: Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder that has defined by hyperactivity, impulsivity and attention deficits. Various neurotransmitters such as dopamine can play a role in its pathophysiology. The aim of this study was to examine the association of two common single nucleotid POLYMORPHISMs in DRD4 gene, a 48 bp VNTR POLYMORPHISM, with attention deficit hyperactivity disorder risk among Iranian-Azeri population.Materials and methods: case–control study was performed on 50 children with attention deficit hyperactivity disorder and 50 healthy ones. Peripheral blood samples were used for Genomic DNA extraction by proteinase K method. The collected data were analyzed through chi-square test (x2), with a significance level of 0.05.Results: considering the obtained results, there was a significant increase in 4.8 genotype frequency between two groups (p<0.05). Although, there was no significant difference in the allele and genotype frequencies in other genotypes between cases and controls (p>0.05).Conclusion: Our data confirmed the relationship between POLYMORPHISM of DRD4 and ADHD. Further studies with larger population of other groups will be required to explain the relationship between DRD4 POLYMORPHISM and the risk of ADHD.

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APA: Copy

HOSSEINPOUREFEIZI, MOHAMMADALI, MEHDIZADEH FANID, LEILA, Noorazar, Seyed Gholamreza, ADAMPOUREZARE, MINA, & GHOLIPOUR FALAHI, MOHAMMADREZA. (2017). STUDYING ASSOCIATION 48 BP POLYMORPHISM OF DRD4 GENE WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER IN CHILDREN FROM NORTH WEST OF IRAN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(5 ), 396-403. SID. https://sid.ir/paper/35879/en

Vancouver: Copy

HOSSEINPOUREFEIZI MOHAMMADALI, MEHDIZADEH FANID LEILA, Noorazar Seyed Gholamreza, ADAMPOUREZARE MINA, GHOLIPOUR FALAHI MOHAMMADREZA. STUDYING ASSOCIATION 48 BP POLYMORPHISM OF DRD4 GENE WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER IN CHILDREN FROM NORTH WEST OF IRAN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(5 ):396-403. Available from: https://sid.ir/paper/35879/en

IEEE: Copy

MOHAMMADALI HOSSEINPOUREFEIZI, LEILA MEHDIZADEH FANID, Seyed Gholamreza Noorazar, MINA ADAMPOUREZARE, and MOHAMMADREZA GHOLIPOUR FALAHI, “STUDYING ASSOCIATION 48 BP POLYMORPHISM OF DRD4 GENE WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER IN CHILDREN FROM NORTH WEST OF IRAN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 5 , pp. 396–403, 2017, [Online]. Available: https://sid.ir/paper/35879/en

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