GENETIC ANALYSIS OF INTEGRONS AMONG METHICILLIN-RESISTANT AND SUSCEPTIBLE STAPHYLOCOCCUS AUREUS ISOLATED FROM NOSOCOMIAL INFECTIONS

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MOATTI SOMAYYEH; SHOJAEE SADI BEHROUZ; GHAZNAVI RAD EHSANOLLAH

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Journal Paper

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Journal: Journal of Arak University Medical Sciences Year:2017 | Volume:20 | Issue:7 (124) Page(s): 89-107

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Title

GENETIC ANALYSIS OF INTEGRONS AMONG METHICILLIN-RESISTANT AND SUSCEPTIBLE STAPHYLOCOCCUS AUREUS ISOLATED FROM NOSOCOMIAL INFECTIONS

Author(s)

MOATTI SOMAYYEH | SHOJAEE SADI BEHROUZ | GHAZNAVI RAD EHSANOLLAH | Issue Writer Certificate

Keywords

INTEGRONQ2

METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUSQ3

METHICILLIN-SUSCEPTIBLE STAPHYLOCOCCUS AUREUSQ3

POLYMERASE CHAIN REACTIONQ1

Abstract

Background: INTEGRONs are mobile genetic elements that play an important role in dissemination of antibiotic resistance genes. The aim of present study is to determine the antibiotic resistance profile, frequency of INTEGRONs genes (class 1, 2, 3) and compare it between MRSA and MSSA isolates from clinical infections.Materials and Methods: 50 MRSA and 50 MSSA isolates from March to September 2015 were isolated from infection site of hospitalized patients referred to Valiasr hospital Arak, Iran were subjected to this study. All isolates were tested for susceptibility to antibiotics using disk diffusion method. Then, the mecA gene was studied to validate resistance. The frequency of INTEGRONs (class 1, 2, 3) and the variable region genes like qacE D 1 and sul1 in isolates were determined by PCR method.Results: The highest antibiotic resistances rate in isolates was found for clindamycin.All of the isolates were susceptibel to vancomycin.80% of MRSA and 40% of the MSSA isolates carried class 1 INTEGRONs, whereas class 2 INTEGRON were found in 12 % and 4% of MRSA and MSSA isolates, respectively. Also, all isolates that were class 1 INTEGRON gene positive contain qacE 1 and sul1 genes. Class 3 INTEGRONs were not found.Conclusion: The high frequency of class 1 INTEGRON in MRSA and MSSA isolates associated with high rate of antibiotic resistance indicating that may be INTEGRONs play an important role facilitating the spread of antimicrobial resistance in this region. Clinical doctors and infection control committee should take this issue seriously.

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References

MOLECULAR INVESTIGATION OF INTEGRONS IN ESCHERICHIA COLIAND KLEBSIELLA PNEUMONIAE ISOLATED FROM URINARY TRACT INFECTIONS

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APA: Copy

MOATTI, SOMAYYEH, SHOJAEE SADI, BEHROUZ, & GHAZNAVI RAD, EHSANOLLAH. (2017). GENETIC ANALYSIS OF INTEGRONS AMONG METHICILLIN-RESISTANT AND SUSCEPTIBLE STAPHYLOCOCCUS AUREUS ISOLATED FROM NOSOCOMIAL INFECTIONS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 20(7 (124)), 89-107. SID. https://sid.ir/paper/358927/en

Vancouver: Copy

MOATTI SOMAYYEH, SHOJAEE SADI BEHROUZ, GHAZNAVI RAD EHSANOLLAH. GENETIC ANALYSIS OF INTEGRONS AMONG METHICILLIN-RESISTANT AND SUSCEPTIBLE STAPHYLOCOCCUS AUREUS ISOLATED FROM NOSOCOMIAL INFECTIONS. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2017;20(7 (124)):89-107. Available from: https://sid.ir/paper/358927/en

IEEE: Copy

SOMAYYEH MOATTI, BEHROUZ SHOJAEE SADI, and EHSANOLLAH GHAZNAVI RAD, “GENETIC ANALYSIS OF INTEGRONS AMONG METHICILLIN-RESISTANT AND SUSCEPTIBLE STAPHYLOCOCCUS AUREUS ISOLATED FROM NOSOCOMIAL INFECTIONS,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 20, no. 7 (124), pp. 89–107, 2017, [Online]. Available: https://sid.ir/paper/358927/en

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