A PROSPECTIVE RANDOMIZED TRIAL OF DILTIAZEM GEL AND GLYCERYL TRINITRATE OINTMENT ON TREATMENT OF CHRONIC ANAL FISSURE

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AKHONDI MEYBODI M.; KARGAR S.; EMADI S.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2014 | Volume:22 | Issue:5 Page(s): 1445-1454

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Title

A PROSPECTIVE RANDOMIZED TRIAL OF DILTIAZEM GEL AND GLYCERYL TRINITRATE OINTMENT ON TREATMENT OF CHRONIC ANAL FISSURE

Author(s)

AKHONDI MEYBODI M. | KARGAR S. | EMADI S. | Issue Writer Certificate

Keywords

ANAL FISSUREQ3

GLYCERYL TRINITRATEQ2

TOPICAL DILTIAZEMQ2

Abstract

Introduction: In this randomized prospective study, 2% - diltiazem topical gel and 0.03% -GTN ointment were compared in patients with chronic ANAL FISSURE. Methods: This semi-experimental study consisted of sixty six outpatients (34 females and 32 males) with chronic ANAL FISSURE, who referred to the gastroenterology clinic. Patients were randomly classified into two groups. Group A received GTN ointment (0.03%), whereas group B was treated with Diltiazem gel (2%). The treatment was administered twice daily for 8 weeks. Healing and side-effects were recorded to be compared after 8 weeks. Results: In group A, the ANAL FISSURE was thoroughly healed within 53.3% of patients, moderately healed for 6.7% of patients and not healed in 25.8% of patients. Moreover, side-effects were noted in 15(46.9%) patients (P= 0.482). Two (6.2%) patients had intolerable headache and discontinued the study, 11 (34.3%) patients suffered from headache and 2 patients (6.2%) were reported to have orthostatic hypotension. In group B, healing occurred in 21(67.7%) out of 31 patients and 1 (3.2%) case of headache was noted(P= 0.0001). Conclusion: The present study has demonstrated that TOPICAL DILTIAZEM can be preferable to GTN owing to the absence of side-effects.

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APA: Copy

AKHONDI MEYBODI, M., KARGAR, S., & EMADI, S.. (2014). A PROSPECTIVE RANDOMIZED TRIAL OF DILTIAZEM GEL AND GLYCERYL TRINITRATE OINTMENT ON TREATMENT OF CHRONIC ANAL FISSURE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 22(5), 1445-1454. SID. https://sid.ir/paper/35902/en

Vancouver: Copy

AKHONDI MEYBODI M., KARGAR S., EMADI S.. A PROSPECTIVE RANDOMIZED TRIAL OF DILTIAZEM GEL AND GLYCERYL TRINITRATE OINTMENT ON TREATMENT OF CHRONIC ANAL FISSURE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(5):1445-1454. Available from: https://sid.ir/paper/35902/en

IEEE: Copy

M. AKHONDI MEYBODI, S. KARGAR, and S. EMADI, “A PROSPECTIVE RANDOMIZED TRIAL OF DILTIAZEM GEL AND GLYCERYL TRINITRATE OINTMENT ON TREATMENT OF CHRONIC ANAL FISSURE,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 1445–1454, 2014, [Online]. Available: https://sid.ir/paper/35902/en

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