PREPARATION OF DILTIAZEM TOPICAL GEL FOR THE TREATMENT OF ANAL FISSURE AND IN-VITRO, EX-VIVO DRUG RELEASE EVALUATIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAVAKOLI N.; MINAIAN M.; SAGHAEI E.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Kerman University of Medical Sciences Year:2007 | Volume:14 | Issue:3 Page(s): 163-175

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

41,057

Download:

Cites:

Information Journal Paper

Title

PREPARATION OF DILTIAZEM TOPICAL GEL FOR THE TREATMENT OF ANAL FISSURE AND IN-VITRO, EX-VIVO DRUG RELEASE EVALUATIONS

Author(s)

TAVAKOLI N. | MINAIAN M. | SAGHAEI E. | Issue Writer Certificate

Keywords

DILTIAZEMQ2

TOPICAL GELQ3

ANAL FISSUREQ3

Abstract

Introduction: ANAL FISSUREs are small tears in the lining skin of the anus presenting with typical symptoms of pain and bleeding during defecation. Several new forms of medicines such as glyceryle trinitrate (GTN) ointments and DILTIAZEM, a calcium channel-blocking agent, have been recently used for the treatment of these fissures. DILTIAZEM relaxes the muscle of anal sphincter and consequently increases blood flow to promote healing. It does not have GTN side effects like headache, anal burning and hypotension. The objective of this study was to formulate a suitable TOPICAL GEL from DILTIAZEM and then to investigate its physicochemical stability and also the drug release profiles from the bases.Methods: Various formulations of gel base including Guar 1.25%, Tragacanth 1.5%, HPMC 1%, and HPMC 1.5% were prepared and in vitro release and penetration characteristics of DILTIAZEM from each preparation were studied through a hydrophilic dora pore diffusion barrier and membrane excised rat skin using Franz cell over a period of 5 hours. The amount of drug released from topical preparations was determined spectrophotometrically at λ max=236 nm. Stability studies and shelf life assessments were performed too.Results: Gel formulations containing HPMC, Guar and Tragacanth presented both good chemical and physical stabilities. The rates of cumulative drug release from HPMC 1%, HPMC 1.5%, Guar 1.25% and Tragacanth 1.5% bases using synthetic membrane were 89.7%, 76.7%, 94.9% and 66.1% respectively. For excised rat skin test, the cumulative percent of penetrated drug at the end of each experiment were 52.7%, 50.9%, 64.6% and 42.6% for HPMC 1%, HPMC 1.5%, Guar 1.25% and Tragacanth 1.5% bases respectively.Conclusion: The comparative study showed that the percent of drug release from synthetic membrane was more than the percent of penetrated drug through excised rat skin for all bases (P<0.05). It was concluded that the kinetics of DILTIAZEM release in vitro was not affected by the kind of gel forming agent and for all of the formulations, Higuchi’s kinetic model was suitable to explain their kinetics.

Cites

A PROSPECTIVE RANDOMIZED TRIAL OF DILTIAZEM GEL AND GLYCERYL TRINITRATE OINTMENT ON TREATMENT OF CHRONIC ANAL FISSURE

References

Cite

APA: Copy

TAVAKOLI, N., MINAIAN, M., & SAGHAEI, E.. (2007). PREPARATION OF DILTIAZEM TOPICAL GEL FOR THE TREATMENT OF ANAL FISSURE AND IN-VITRO, EX-VIVO DRUG RELEASE EVALUATIONS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 14(3), 163-175. SID. https://sid.ir/paper/361/en

Vancouver: Copy

TAVAKOLI N., MINAIAN M., SAGHAEI E.. PREPARATION OF DILTIAZEM TOPICAL GEL FOR THE TREATMENT OF ANAL FISSURE AND IN-VITRO, EX-VIVO DRUG RELEASE EVALUATIONS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;14(3):163-175. Available from: https://sid.ir/paper/361/en

IEEE: Copy

N. TAVAKOLI, M. MINAIAN, and E. SAGHAEI, “PREPARATION OF DILTIAZEM TOPICAL GEL FOR THE TREATMENT OF ANAL FISSURE AND IN-VITRO, EX-VIVO DRUG RELEASE EVALUATIONS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 3, pp. 163–175, 2007, [Online]. Available: https://sid.ir/paper/361/en

Related Journal Papers