DESIGNING OF HUMAN CARTILAGE TISSUE, BY DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS WITH BMP-6 IN ALGINATE SCAFFOLD

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HASHEMI BANI B.; RAZAVI SHAHNAZ; ESFANDIARI EBRAHIM; KARBASI S.; MARDANI MOHAMMAD; NADALI FATEMEH; SADEGHI FARZANEH; HAGHIGHAT F.; HAGHJOU SHAGHAYEGH; GOUHARIAN V.

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Journal: Anatomical Sciences Journal Year:2010 | Volume:8 | Issue:31 Page(s): 117-127

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Title

DESIGNING OF HUMAN CARTILAGE TISSUE, BY DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS WITH BMP-6 IN ALGINATE SCAFFOLD

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Keywords

ADIPOSE-DERIVED STEM CELLSQ3

ALGINATEQ3

BMP-6Q3

TISSUE ENGINEERINGQ2

CHONDROGENESISQ2

Abstract

Purpose: In the present study the effect of BMP-6 was investigated on CHONDROGENESIS of adiposederived stem cells. Materials and Methods: Mesenchymal stem cells derived from subcutaneous adipose tissue were cultured on ALGINATE scaffold to induce CHONDROGENESIS in experimental group, with chondrogenic medium having BMP-6 growth factor for 3 weeks. In control group medium without BMP-6 was applied. The harvested constructs were examined with immunohistochemical and RT-PCR methods for assessment of cartilage-specific characteristics. Results: The results of immunohistochemical method revealed the presence of typical cartilage extracellular matrix components such as type II collagen and aggrecan in constructs induced by BMP-6 growth factor on ALGINATE scaffold. In addition evaluation of the results of RT-PCR analysis confirmed the expression of cartilage- specific genes, such as type II collagen and aggrecan, in the differentiated cells under the influence of growth factor BMP-6. Conclusion: It can be concluded that BMP-6 promotes CHONDROGENESIS of ADSC in 3-D and ADIPOSE-DERIVED STEM CELLS could be used for cartilage TISSUE ENGINEERING.

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APA: Copy

HASHEMI BANI, B., RAZAVI, SHAHNAZ, ESFANDIARI, EBRAHIM, KARBASI, S., MARDANI, MOHAMMAD, NADALI, FATEMEH, SADEGHI, FARZANEH, HAGHIGHAT, F., HAGHJOU, SHAGHAYEGH, & GOUHARIAN, V.. (2010). DESIGNING OF HUMAN CARTILAGE TISSUE, BY DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS WITH BMP-6 IN ALGINATE SCAFFOLD. JOURNAL OF IRANIAN ANATOMICAL SCIENCES, 8(31), 117-127. SID. https://sid.ir/paper/359092/en

Vancouver: Copy

HASHEMI BANI B., RAZAVI SHAHNAZ, ESFANDIARI EBRAHIM, KARBASI S., MARDANI MOHAMMAD, NADALI FATEMEH, SADEGHI FARZANEH, HAGHIGHAT F., HAGHJOU SHAGHAYEGH, GOUHARIAN V.. DESIGNING OF HUMAN CARTILAGE TISSUE, BY DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS WITH BMP-6 IN ALGINATE SCAFFOLD. JOURNAL OF IRANIAN ANATOMICAL SCIENCES[Internet]. 2010;8(31):117-127. Available from: https://sid.ir/paper/359092/en

IEEE: Copy

B. HASHEMI BANI, SHAHNAZ RAZAVI, EBRAHIM ESFANDIARI, S. KARBASI, MOHAMMAD MARDANI, FATEMEH NADALI, FARZANEH SADEGHI, F. HAGHIGHAT, SHAGHAYEGH HAGHJOU, and V. GOUHARIAN, “DESIGNING OF HUMAN CARTILAGE TISSUE, BY DIFFERENTIATION OF ADIPOSE-DERIVED STEM CELLS WITH BMP-6 IN ALGINATE SCAFFOLD,” JOURNAL OF IRANIAN ANATOMICAL SCIENCES, vol. 8, no. 31, pp. 117–127, 2010, [Online]. Available: https://sid.ir/paper/359092/en

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