The estimation of body organs absorbed dose induced by 99mTc – MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method

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Taghizadeh Sedigheh; PARACH ALI ASGHAR; RAZAVI RATKI SEID KAZEM; BAGHERI MAHMOUD

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:6 Page(s): 463-472

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Title

The estimation of body organs absorbed dose induced by 99mTc – MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method

Author(s)

Taghizadeh Sedigheh | PARACH ALI ASGHAR | RAZAVI RATKI SEID KAZEM | BAGHERI MAHMOUD | Issue Writer Certificate

Keywords

Internal absorbed doseQ1

Combined SPECT/Planar methodQ1

Mirdose softwareQ1

Cumulated activityQ1

Abstract

Introduction: Bone scan is a nuclear medicine scan test, which leads to finding specific abnormalities in the bone. Methylene Diphosphonate (MDP) is used to bone scan. This combination is absorbed by bone tissue and is excreted by the kidneys and bladder. The purpose of this study was to estimate the absorbed dose of organs in bone scan with injection MDP radiopharmaceutical by specific dosimetry and the SPECT/planar hybrid method. Methods: 20 females who referred to the Nuclear Medicine Department for bone disorders were examined and three planar images intervals of 1, 3 and 5 hours and one SPECT at 3 hours after injection were taken from them. The cumulative activity of the organs was obtained using the SPECT/planar hybrid method and then the absorbed dose was calculated using Mirdose software. Results: The mean absorbed dose due to 99mTc-MDP in women for heart wall (0. 0026± 0. 0005), kidneys (0. 043± 0. 0072), liver (0. 0034± 0. 0001), lungs (0. 0024± 0. 0001), muscle (0. 0028± 0. 0006), ovaries (0. 0056± 0. 0004), spleen (0. 0048± 0. 0003), urinary bladder wall (0. 0680± 0. 0120), bones (0. 0046± 0. 0006) and reminder of the body (0. 0031± 0. 00096) mGy/MBq were obtained. Conclusion: Bladder, kidneys, ovaries, spleen, bones, liver, muscles, walls of the heart and lungs have the highest rates of absorbed dose in organs, respectively. Since the women studied in this study had different diseases, bone disorders, and biological characteristics, and some of them were metastatic due to the disease, this led to a different absorption of radiopharmaceuticals in the various organs of these patients, which caused the differences in the average absorbed dose of radiopharmaceuticals in their organs.

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APA: Copy

Taghizadeh, Sedigheh, PARACH, ALI ASGHAR, RAZAVI RATKI, SEID KAZEM, & BAGHERI, MAHMOUD. (2018). The estimation of body organs absorbed dose induced by 99mTc – MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(6 ), 463-472. SID. https://sid.ir/paper/36057/en

Vancouver: Copy

Taghizadeh Sedigheh, PARACH ALI ASGHAR, RAZAVI RATKI SEID KAZEM, BAGHERI MAHMOUD. The estimation of body organs absorbed dose induced by 99mTc – MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(6 ):463-472. Available from: https://sid.ir/paper/36057/en

IEEE: Copy

Sedigheh Taghizadeh, ALI ASGHAR PARACH, SEID KAZEM RAZAVI RATKI, and MAHMOUD BAGHERI, “The estimation of body organs absorbed dose induced by 99mTc – MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 6 , pp. 463–472, 2018, [Online]. Available: https://sid.ir/paper/36057/en

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