NEUROTOXIC EFFECTS OF HEXACHLOROBUTADIENE (HCBD) ON THE YOUNG MALE W/A RAT

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BOROUSHAKI M.T.; GRASSO P.; GOLDFARB P.S.

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Journal: Iranian Journal of Basic Medical Sciences Year:2003 | Volume:6 | Issue:2 (18) Page(s): 5-10

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Title

NEUROTOXIC EFFECTS OF HEXACHLOROBUTADIENE (HCBD) ON THE YOUNG MALE W/A RAT

Author(s)

BOROUSHAKI M.T. | GRASSO P. | GOLDFARB P.S. | Issue Writer Certificate

Keywords

HCBDQ4

CHOROID PLEXUSQ4

NEUROTOXICITYQ3

Abstract

Hexachlorobutadiene (HCBD), a by-product in the synthesis of perchloroethylene and trichloroethylene and a prominent environmental pollutant, is one of the most nephrotoxic chlorinated-hydrocarbons in rodents. Its organ-specific toxicity is based on a bioactivation mechanism that includes hepatic conjugation with glutathione to produce (penta-chloro, butadienyl)-glutathione (PCBG) and finally to (pentachloro butadienyl)-cysteine (PCBC), translocation and subsequent enzymatic degradation to toxic metabolites by the enzyme C-S-lyase/GTK/KAT. In this study we attempted to determine whether HCBD is a site-specific neurotoxin in the young rat. In this research, 28-day old male Wistar albino (W/A) rats were used. Groups of rats received daily doses of HCBD 25mg /kg, ip (low dose), for 2, 3, 4 and 7 days and 100mg/kgbody weight, ip (high dose), for one and two days. Control group received corn oil, 1ml /kg, ip. Animals were killed, the brain removed, halved, one half fixed in formalin and embedded in paraffin for histopathology and the other half was frozen in dried-ice isopantane for enzyme assay. Sections of 5 µm were prepared and stained with hematoxylin and eosin. Light microscopic examination showed an extensive damage in the choroids plexus of lateral and third ventricles in HCBD treated rats, especially in 1-day HCBD (100mg/kg) treated group, compare with control and other groups. In groups treated with low dose of HCBD there is a minor haemorrhage in lateral ventricles with pyknotic and mitotic figures in coroidal cells. Glutamine transaminase K (GTK) specific activity in high dose treated groups was lower than control group. In low dose treated groups GTK specific activity showed higher, but not significantly, than that of control group. In high dose treated groups the activity of GTK was lower than control. Data have shown that HCBD is a neurotoxin and CHOROID PLEXUS in the lateral and third ventricles is the most sensitive organ that is affected.

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APA: Copy

BOROUSHAKI, M.T., GRASSO, P., & GOLDFARB, P.S.. (2003). NEUROTOXIC EFFECTS OF HEXACHLOROBUTADIENE (HCBD) ON THE YOUNG MALE W/A RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 6(2 (18)), 5-10. SID. https://sid.ir/paper/360671/en

Vancouver: Copy

BOROUSHAKI M.T., GRASSO P., GOLDFARB P.S.. NEUROTOXIC EFFECTS OF HEXACHLOROBUTADIENE (HCBD) ON THE YOUNG MALE W/A RAT. IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES[Internet]. 2003;6(2 (18)):5-10. Available from: https://sid.ir/paper/360671/en

IEEE: Copy

M.T. BOROUSHAKI, P. GRASSO, and P.S. GOLDFARB, “NEUROTOXIC EFFECTS OF HEXACHLOROBUTADIENE (HCBD) ON THE YOUNG MALE W/A RAT,” IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, vol. 6, no. 2 (18), pp. 5–10, 2003, [Online]. Available: https://sid.ir/paper/360671/en

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