The Effect of Maternal High-Fat Feeding on Energy Homeostasis in Stressed Adult Male Rat Offspring

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KARBASCHI R.; ZARDOOZ H.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2019 | Volume:21 | Issue:1 Page(s): 27-36

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Title

The Effect of Maternal High-Fat Feeding on Energy Homeostasis in Stressed Adult Male Rat Offspring

Author(s)

KARBASCHI R. | ZARDOOZ H. | Issue Writer Certificate

Keywords

Maternal high-fat dietQ1

Energy homeostasisQ1

StressQ2

OffspringQ1

Abstract

Introduction: In the present study the effect of chronic Maternal high-fat diet consumption on Energy homeostasis and glucose metabolism in response to chronic Stress was investigated in adult male rats. Materials and Methods: Female rats were divided into two groups of normal and high fat diets. Each group received their diet from 3 weeks before pregnancy until the end of lactation. At 8 weeks of age, male Offspring were divided into control and Stress groups, the Stress group receiving variable Stress for 2 weeks. At the end of 10 weeks, plasma concentrations of glucose, insulin, corticosterone and leptin were measured and intra-abdominal fat was weighed in all male Offspring. The body weight, food and calorie intake of the rats were also measured. Results: Maternal high-fat diet alone reduced intra-abdominal fat weight, plasma concentrations of corticosterone and leptin, body weight, food and calorie intake, although at had no effect on fasting plasma glucose and insulin concentrations, or on HOMA-IR index. In response to Stress, the Maternal high-fat diet reduced corticosterone and leptin plasma concentrations, body weight, food and calorie intake compared to the control group; whereas did not significantly change the intra-abdominal fat weight, plasma glucose and insulin levels as well as HOMA-IR index. Conclusion: From the results of the present study it seems we can conclude that maternal HFD feeding, in a critical developmental period (perinatal), by altering responsiveness of hypothalamicpituitary-adrenal axis and/or central leptin sensitivity, exacerbates impaired Energy homeostasis in Stressed adult Offspring.

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APA: Copy

KARBASCHI, R., & ZARDOOZ, H.. (2019). The Effect of Maternal High-Fat Feeding on Energy Homeostasis in Stressed Adult Male Rat Offspring. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 21(1 ), 27-36. SID. https://sid.ir/paper/361084/en

Vancouver: Copy

KARBASCHI R., ZARDOOZ H.. The Effect of Maternal High-Fat Feeding on Energy Homeostasis in Stressed Adult Male Rat Offspring. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2019;21(1 ):27-36. Available from: https://sid.ir/paper/361084/en

IEEE: Copy

R. KARBASCHI, and H. ZARDOOZ, “The Effect of Maternal High-Fat Feeding on Energy Homeostasis in Stressed Adult Male Rat Offspring,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 21, no. 1 , pp. 27–36, 2019, [Online]. Available: https://sid.ir/paper/361084/en

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