ALUMINIUM EFFECT ON ELECTRICAL VAGAL STIMULATION INDUCED GASTRIC ACID SECRETION IN RATS

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KOMEIL Q.; ZAHEDIASL S.; GHARIB NASERI MOHAMMAD KAZEM

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Paper Information

Journal: Zahedan Journal of Research in Medical Sciences Year:2001 | Volume:3 | Issue:2 Page(s): 0-0

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Title

ALUMINIUM EFFECT ON ELECTRICAL VAGAL STIMULATION INDUCED GASTRIC ACID SECRETION IN RATS

Author(s)

KOMEIL Q. | ZAHEDIASL S. | GHARIB NASERI MOHAMMAD KAZEM | Issue Writer Certificate

Keywords

GASTRIC ACID SECRETIONQ4

VAGUS NERVEQ3

ALUMINIUMQ3

RATQ2

Abstract

New Page 1 For many years, ALUMINIUM - containing antacids have been used. According to basic role of calcium in GASTRIC ACID SECRETION, and inhibitory effect of ALUMINIUM on voltage - dependent calcium channels, this study were designed. Vagal stimulation was used for gastric acid induction in this experment. For this purpose, after anesthesia (nesdonal, 60 mg/kg) and gastric cannulation, cervical vagotomy was perorrned in RATs. Also, heart RATe was recorded before and after vagotomy. After bilateral vagotomy, pelipheral end of vagusnerves (left or right) stimulated with 12V, 4Hz and 1 msec width current for 15 min. Gastric secretory response to right or left vagal stimulation do not different significantly. Gastric-acid output was measured with wash out method in 15-min intervals during stimulation period until return to basal acid level.Aluminium (10 or 50 pg/kg) injected from tail vein, 2 min before second time of .stimulation,and acid output was measured in a same time. Statisical analysis was peiforrned by paired t-test. In first group (10 µg/kg AI,n =8) vagal stimulation increased acid output significantly (from 3.5 ± 0.12 to 35.2 ± 2.3 µmol/15min, P<0.000l )and ALUMINIUM injection has no significant effect. In second group (50 µg/kgAI, n=8) gastric acid secretion was inhibited with ALUMINIUM significantly (P<0.00l ). Therefore, it seems that inhibitory effect of ALUMINIUM on acid secretion is dose-dependent. In addition to buffering of ALUMINIUM,it has an inhibitory effect on gastric acid secretion in RAT.

Cites

TOXIC EFFECT OF ALUMINUM

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APA: Copy

KOMEIL, Q., ZAHEDIASL, S., & GHARIB NASERI, MOHAMMAD KAZEM. (2001). ALUMINIUM EFFECT ON ELECTRICAL VAGAL STIMULATION INDUCED GASTRIC ACID SECRETION IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 3(2), 0-0. SID. https://sid.ir/paper/361180/en

Vancouver: Copy

KOMEIL Q., ZAHEDIASL S., GHARIB NASERI MOHAMMAD KAZEM. ALUMINIUM EFFECT ON ELECTRICAL VAGAL STIMULATION INDUCED GASTRIC ACID SECRETION IN RATS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2001;3(2):0-0. Available from: https://sid.ir/paper/361180/en

IEEE: Copy

Q. KOMEIL, S. ZAHEDIASL, and MOHAMMAD KAZEM GHARIB NASERI, “ALUMINIUM EFFECT ON ELECTRICAL VAGAL STIMULATION INDUCED GASTRIC ACID SECRETION IN RATS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 3, no. 2, pp. 0–0, 2001, [Online]. Available: https://sid.ir/paper/361180/en

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