Effects of Eight Weeks of Aerobic Training on Expression Levels of the HMGB1-RAGE/TLR4-NF-kB Proinflammatory Pathway in Cardiac Tissue of Male Rats with Hyperglycemia

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Taghibeigi Hoseinabadi H.; ESFARJANI F.; MARANDI S.M.; KARAMI H.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2018 | Volume:20 | Issue:5 Page(s): 246-252

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Title

Effects of Eight Weeks of Aerobic Training on Expression Levels of the HMGB1-RAGE/TLR4-NF-kB Proinflammatory Pathway in Cardiac Tissue of Male Rats with Hyperglycemia

Author(s)

Taghibeigi Hoseinabadi H. | ESFARJANI F. | MARANDI S.M. | KARAMI H. | Issue Writer Certificate

Keywords

Aerobic TrainingQ2

HMGB1Q1

RAGEQ1

TLR4 and NF-kBQ1

Diabetic CardiomyopathyQ1

HyperglycemiaQ1

Abstract

Introduction: Inflammation plays a critical role in the pathogenesis of Diabetic Cardiomyopathy. The expression of HMGB1, a proinflammatory cytokine, and its downstream signaling pathway is upregulated in diabetes. The aim of this study was to investigate the effect of 8 weeks Aerobic Training on the expression levels of the HMGB1-RAGE/TLR4-NF-kB pathway in cardiac tissue of male rats with Hyperglycemia. Materials and Methods: Thirty-six male Wistar rats (mean weight, 231± 25g) were randomly divided into three groups (n=12 each): Healthy control, control Hyperglycemia and trained Hyperglycemia. Hyperglycemia was induced by intraperitoneal injection of streptozotocin and nicotinamide. Forty-eight hours after completion of the training program (eight weeks Aerobic Training), cardiac tissue was removed under sterile conditions. Gene expression of HMGB1, RAGE, TLR4 and NF-kB were investigated, using Real-time PCR. For data analysis, one-way ANOVA and post-hoc Tukey’ s test were used, with P<0. 05 considered statistically significant. Results: Gene expression levels of HMGB1, RAGE, TLR4 and NF-kB were significantly (P=0. 001) increased in the cardiac tissue of the hyperglycemic control group, compared with healthy controls. Eight weeks of Aerobic Training decreased the expression levels of the studied genes (P=0. 001). Conclusion: It seems that Aerobic Training can prevent the negative effects of Hyperglycemia via by attenuating gene expression levels of HMGB1, RAGE, TLR4 and NF-kB in the cardiac tissue of rats with Hyperglycemia, and could hence be an important mechanism for cardiac function and preventing Diabetic Cardiomyopathy.

Cites

Effect of a 6-week Aerobic Exercise Program on High-mobility Group Box 1 Gene Expression in Aortic Tissue of Diabetic Rats

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APA: Copy

Taghibeigi Hoseinabadi, H., ESFARJANI, F., MARANDI, S.M., & KARAMI, H.. (2018). Effects of Eight Weeks of Aerobic Training on Expression Levels of the HMGB1-RAGE/TLR4-NF-kB Proinflammatory Pathway in Cardiac Tissue of Male Rats with Hyperglycemia. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 20(5 ), 246-252. SID. https://sid.ir/paper/362317/en

Vancouver: Copy

Taghibeigi Hoseinabadi H., ESFARJANI F., MARANDI S.M., KARAMI H.. Effects of Eight Weeks of Aerobic Training on Expression Levels of the HMGB1-RAGE/TLR4-NF-kB Proinflammatory Pathway in Cardiac Tissue of Male Rats with Hyperglycemia. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;20(5 ):246-252. Available from: https://sid.ir/paper/362317/en

IEEE: Copy

H. Taghibeigi Hoseinabadi, F. ESFARJANI, S.M. MARANDI, and H. KARAMI, “Effects of Eight Weeks of Aerobic Training on Expression Levels of the HMGB1-RAGE/TLR4-NF-kB Proinflammatory Pathway in Cardiac Tissue of Male Rats with Hyperglycemia,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 20, no. 5 , pp. 246–252, 2018, [Online]. Available: https://sid.ir/paper/362317/en

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