PROTECTIVE EFFECTS OF STEM CELL FACTOR IN INHIBITING X-RAYS INDUCED APOPTOSIS IN HL60 CELLS

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HOSSEINIMEHR S.J.; INANAMI O.; KUWABARA M.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2005 | Volume:15 | Issue:46 Page(s): 25-31

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Title

PROTECTIVE EFFECTS OF STEM CELL FACTOR IN INHIBITING X-RAYS INDUCED APOPTOSIS IN HL60 CELLS

Author(s)

HOSSEINIMEHR S.J. | INANAMI O. | KUWABARA M. | Issue Writer Certificate

Keywords

APOPTOSISQ1

CYTOKINEQ2

SCFQ4

IRRADIATIONQ2

Abstract

Background and purpose: APOPTOSIS or programmed cell death is a process of cell suicide. Ionizing radiation is one of the stimuli for APOPTOSIS, acting through DNA damage. In the present study, effects of X-rays induced APOPTOSIS in HL60 cells, as well as the protective effects of Stem Cell Factor (SCF) in inhibiting X-ray induced APOPTOSIS have been evaluated.Materials and methods: HL60 cells were exposed to 5 Gy of x-ray and the effect of time on the percentage of apoptotic cells was studied. One group of cells was incubated in medium containing SCF at 37°C for 1 h before X-ray exposure. Other groups of cells were incubated in media containing SCF, MAPK, PI3K and PKC inhibitors as the cellular pathway proteins, and the X-ray induced APOPTOSIS was studied.Results: The X-ray induced APOPTOSIS show a graduall increase from 12h to 60h after X-ray. The SCF attenuated the percentage of apoptotic cells when cells were treated with SCF 1 h before X-ray. X-rays induced APOPTOSIS partially attenuated by a combination treatment of SCF and PKC and PI3K inhibitors, but it was not inhibited by the SCF and ERK inhibitors.Conclusion: SCF protected cells against X-rays through activation of MAPK pathway.

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APA: Copy

HOSSEINIMEHR, S.J., INANAMI, O., & KUWABARA, M.. (2005). PROTECTIVE EFFECTS OF STEM CELL FACTOR IN INHIBITING X-RAYS INDUCED APOPTOSIS IN HL60 CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 15(46), 25-31. SID. https://sid.ir/paper/362372/en

Vancouver: Copy

HOSSEINIMEHR S.J., INANAMI O., KUWABARA M.. PROTECTIVE EFFECTS OF STEM CELL FACTOR IN INHIBITING X-RAYS INDUCED APOPTOSIS IN HL60 CELLS. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2005;15(46):25-31. Available from: https://sid.ir/paper/362372/en

IEEE: Copy

S.J. HOSSEINIMEHR, O. INANAMI, and M. KUWABARA, “PROTECTIVE EFFECTS OF STEM CELL FACTOR IN INHIBITING X-RAYS INDUCED APOPTOSIS IN HL60 CELLS,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 46, pp. 25–31, 2005, [Online]. Available: https://sid.ir/paper/362372/en

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