Effect of aerobic exercise on some factors of cardiac apoptosis in male rats

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Sadighi Aghil; ABDI AHMAD; AZARBAYJANI MOHAMMAD ALI; BARARI ALIREZA

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Journal: Feyz Medical Sciences Journal Year:2020 | Volume:23 | Issue:5 Page(s): 495-502

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Title

Effect of aerobic exercise on some factors of cardiac apoptosis in male rats

Author(s)

Sadighi Aghil | ABDI AHMAD | AZARBAYJANI MOHAMMAD ALI | BARARI ALIREZA | Issue Writer Certificate

Keywords

Exercise trainingQ1

Cardiac diseaseQ2

Caspase3Q1

BaxQ1

Bcl2Q1

Abstract

Background: Cardiac apoptosisplays an important role in myocardial diseases. Current evidence suggests that Exercise training may modify some apoptosis-related signaling in myocardium. This study aimedto investigate the effect of aerobic training on cardiac Bax, Bcl2 and caspase-3 inmale rats. Materials and Methods: In this experimental study, Sixteen Wistar male rats 10 weeks old with 299. 74± 19. 32 g weight were randomly classified into control and training groups. Training groups have performed an aerobic running program (at 10-18 m/min, 10-40 min/day, and 5 days/week) on a motor-driven treadmill for six weeks. Forty eight hours after the last training session, rats were sacrificed; hearts were excised and immediately frozen in liquid nitrogen and stored at-80 ° C. Bax, Bcl2 and Caspase3 protein expression were evaluated by ELISA and western blot. Data were analyzed using Independent t-test and ANCOVA at P<0. 05. Result: The results showed that six weeks aerobic training significantly decreased heart Bax in rats (P=0. 045). Also heart Bcl2 (P=0. 003) and caspase-3 (P=0. 040) were significantly increased in comparison to the training group. Conclusion: Moderate-intensity aerobic exercise seems to modify some factors affecting the apoptosis of the heart tissue of male rats.

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APA: Copy

Sadighi, Aghil, ABDI, AHMAD, AZARBAYJANI, MOHAMMAD ALI, & BARARI, ALIREZA. (2020). Effect of aerobic exercise on some factors of cardiac apoptosis in male rats. FEYZ, 23(5 ), 495-502. SID. https://sid.ir/paper/362411/en

Vancouver: Copy

Sadighi Aghil, ABDI AHMAD, AZARBAYJANI MOHAMMAD ALI, BARARI ALIREZA. Effect of aerobic exercise on some factors of cardiac apoptosis in male rats. FEYZ[Internet]. 2020;23(5 ):495-502. Available from: https://sid.ir/paper/362411/en

IEEE: Copy

Aghil Sadighi, AHMAD ABDI, MOHAMMAD ALI AZARBAYJANI, and ALIREZA BARARI, “Effect of aerobic exercise on some factors of cardiac apoptosis in male rats,” FEYZ, vol. 23, no. 5 , pp. 495–502, 2020, [Online]. Available: https://sid.ir/paper/362411/en

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