The effect of a period of progressive endurance training on the apoptotic regulator markers in serum of Wistar rats with myocardial infarction

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KHANSOOZ MOJTABA; ABEDI BAHRAM; PALIZVAN MOHAMMAD REZA; SAREMI ABBAS

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Journal: Journal of Sport Biosciences Year:2020 | Volume:12 | Issue:1 Page(s): 109-126

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Title

The effect of a period of progressive endurance training on the apoptotic regulator markers in serum of Wistar rats with myocardial infarction

Author(s)

KHANSOOZ MOJTABA | ABEDI BAHRAM | PALIZVAN MOHAMMAD REZA | SAREMI ABBAS | Issue Writer Certificate

Keywords

Cardiac InfarctionQ1

Endurance TrainingQ2

Cytochrome CQ1

Caspase-3Q1

Caspase-8Q1

Abstract

Cardiovascular disease, due to its chronicity, often affects everyday activities of the individual and is the leading cause of death in the world. The purpose of this study was to investigate the effect of progressive Endurance Training on adjustment indicators Apoptosis is indicated in samples of patients with myocardial infarction. Methodology: The present study is an experimental study In this study, 20 Wistar rats, aged 8-10 weeks, weighing 230± 30 g were randomly divided into two groups of infarction control (Sed. MI) and infarction training (Ex. MI). After induction of myocardial infarction by two intraperitoneal injections of isoproterenol at a 24-hour interval at a dose of 150 mg/kg, the training group performed a progressive Endurance Training protocol on the treadmill for eight weeks. Blood samples were taken at the same conditions and at least 24 hours after the last training session and ELISA method was used to measure study variables. Independent t-test was used to evaluate the significant changes in Caspase-8, cytochrome-C and Caspase-3 levels in the pad graph program. The results showed that serum level of Caspase-8, cytochrome-C and Caspase-3 were changes in Ex. MI group than in Sed. MI group. This changes was not significant in the cases of Caspase-3(p=0. 65) and cytochrome-c (p=0. 25) between Sed. MI and Ex. MI. But changes in Caspase-8 values showed significant differences (p=0. 04). According to the results of this study, it seems that application of nonpharmacological strategies such as progressive Endurance Training cannot improve apoptosis rate in samples with myocardial infarction.

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APA: Copy

KHANSOOZ, MOJTABA, ABEDI, BAHRAM, PALIZVAN, MOHAMMAD REZA, & SAREMI, ABBAS. (2020). The effect of a period of progressive endurance training on the apoptotic regulator markers in serum of Wistar rats with myocardial infarction. SPORT BIOSCIENCES (HARAKAT), 12(1 ), 109-126. SID. https://sid.ir/paper/378166/en

Vancouver: Copy

KHANSOOZ MOJTABA, ABEDI BAHRAM, PALIZVAN MOHAMMAD REZA, SAREMI ABBAS. The effect of a period of progressive endurance training on the apoptotic regulator markers in serum of Wistar rats with myocardial infarction. SPORT BIOSCIENCES (HARAKAT)[Internet]. 2020;12(1 ):109-126. Available from: https://sid.ir/paper/378166/en

IEEE: Copy

MOJTABA KHANSOOZ, BAHRAM ABEDI, MOHAMMAD REZA PALIZVAN, and ABBAS SAREMI, “The effect of a period of progressive endurance training on the apoptotic regulator markers in serum of Wistar rats with myocardial infarction,” SPORT BIOSCIENCES (HARAKAT), vol. 12, no. 1 , pp. 109–126, 2020, [Online]. Available: https://sid.ir/paper/378166/en

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