Study of the inhibitory effects of n-heterocycles, magnesium oxide nanoparticles, nisin and poly-l-lysine on Enterobacter aerogenes (hospital pathogen)

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Sarboozi Hossain Abadi Tahere; Beyzaei Hamid; HASHEMI SEYED HADI; HASHEMI SEYED HADI; GHASEMI BEHZAD; Smaily Amir

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:7 Page(s): 57-65

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Title

Study of the inhibitory effects of n-heterocycles, magnesium oxide nanoparticles, nisin and poly-l-lysine on Enterobacter aerogenes (hospital pathogen)

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Keywords

heterocyclic derivativesQ1

Magnesium oxide nanoparticlesQ1

NisinQ2

poly-L-lysineQ1

E.aerogenesQ1

Abstract

Background: Enterobacter aerogenes (E. aerogenes) is one of the causes of hospitalacquired infections, which its standard strains quickly become resistant to the antibiotics. The discovery of new inhibitory agents against this pathogen is constantly expanding. In this study, the inhibitory effects of several synthetic chemical compounds including Magnesium oxide nanoparticles and thiazole, imidazolidine and tetrahydropyrimidine derivatives and natural compounds including Nisin and poly-L-lysine were evaluated against E. aerogenes. Methods: The project is an experimental study. Solutions of all compounds with a specific initial concentration were prepared in 10% DMSO. Antibiogram tests were performed by disc diffusion and broth micro dilution methods according to CLSI guidelines. Results: Thiazole and tetrahydropyrimidine derivatives, Magnesium oxide nanoparticles, Nisin and poly-L-lysine had no inhibitory effects on E. aerogenes. Only, imidazolidines 10a and 10c were effective against E. aerogenes with Inhibition Zone Diameter (IZD) = 6. 12 and 11. 52 mm, Minimum Inhibitory Concentration (MIC) = 1024 and 256 μ g/ml, and Minimum Bactericidal Concentration (MBC) = 2048 and 512 μ g/ml, respectively. Conclusion: The inhibitory effects of imidazolidines10a and 10c were proved on the standard strains of E. aerogenes. Design and synthesis of new and more effective derivatives having imidazolidine skeletons can be considered in future studies.

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APA: Copy

Sarboozi Hossain Abadi, Tahere, Beyzaei, Hamid, HASHEMI, SEYED HADI, GHASEMI, BEHZAD, & Smaily, Amir. (2019). Study of the inhibitory effects of n-heterocycles, magnesium oxide nanoparticles, nisin and poly-l-lysine on Enterobacter aerogenes (hospital pathogen). RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(7 ), 57-65. SID. https://sid.ir/paper/362527/en

Vancouver: Copy

Sarboozi Hossain Abadi Tahere, Beyzaei Hamid, HASHEMI SEYED HADI, GHASEMI BEHZAD, Smaily Amir. Study of the inhibitory effects of n-heterocycles, magnesium oxide nanoparticles, nisin and poly-l-lysine on Enterobacter aerogenes (hospital pathogen). RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(7 ):57-65. Available from: https://sid.ir/paper/362527/en

IEEE: Copy

Tahere Sarboozi Hossain Abadi, Hamid Beyzaei, SEYED HADI HASHEMI, BEHZAD GHASEMI, and Amir Smaily, “Study of the inhibitory effects of n-heterocycles, magnesium oxide nanoparticles, nisin and poly-l-lysine on Enterobacter aerogenes (hospital pathogen),” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 7 , pp. 57–65, 2019, [Online]. Available: https://sid.ir/paper/362527/en

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