STUDY ON ANTIBACTERIAL EFFECT OF NEW THIAZOLE AND IMIDAZOLE DERIVATIVES ON ZOONOSES BACTERIAL PATHOGEN

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GHASEMI BEHZAD; Beyzaei Hamid; HASHEMI SEYED HADI; ASKARI VAHID REZA

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Journal: Journal of Sabzevar University of Medical Sciences Year:2017 | Volume:23 | Issue:5 Page(s): 762-769

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Title

STUDY ON ANTIBACTERIAL EFFECT OF NEW THIAZOLE AND IMIDAZOLE DERIVATIVES ON ZOONOSES BACTERIAL PATHOGEN

Author(s)

GHASEMI BEHZAD | Beyzaei Hamid | HASHEMI SEYED HADI | ASKARI VAHID REZA | Issue Writer Certificate

Keywords

ANTIBACTERIALQ2

THIAZOLEQ1

IMIDAZOLEQ3

Abstract

Backgrounds: Drug resistance in zoonotic bacterial pathogens is a serious risk, which threatens the prosperity and profitability of livestock industry and also public health. To confront this threat, it is necessary to determine and use novel ANTIBACTERIAL compounds on the resistant bacteria. THIAZOLE and IMIDAZOLE derivatives are the novel ANTIBACTERIAL agents; the current study aimed at assessing the ANTIBACTERIAL effect of 1 THIAZOLE derivative and 2 IMIDAZOLE derivatives on Rhodococcus equi, Brucella abortus, and Pasteurella multocida.Methods & Materials: To investigate the ANTIBACTERIAL effect of selected antibiotics, the disk diffusion method was used and the diameter of growth inhibition zone was also measured; the serial dilution method in micro-plates was also employed to assess the minimum inhibitory concentrations (MICs).Results: The results showed that none of the THIAZOLE and IMIDAZOLE derivatives had inhibitory effect on B. aabortus. IMIDAZOLE derivatives also lacked any inhibitory clue on the tested bacteria. The inhibitory effect was only observed in the THIAZOLE derivative with MICs of 128 and 16 mg/mL, and growth inhibition zone diameter of 19.3±0.2 and 28.1±0.3 mm on R. equi and P. multocida, respectively. Conclusion: The inhibitory effect of THIAZOLE derivative was observed on R. equi and P. multocidawas. This antibiotic also showed more inhibitory effects on P. multocida.

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References

EVALUATION OF ANTIBACTERIAL EFFECTS OF BENZOTHIAZOLE DERIVATIVES ON BACTERIAL FOOD PATHOGENS

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APA: Copy

GHASEMI, BEHZAD, Beyzaei, Hamid, HASHEMI, SEYED HADI, & ASKARI, VAHID REZA. (2017). STUDY ON ANTIBACTERIAL EFFECT OF NEW THIAZOLE AND IMIDAZOLE DERIVATIVES ON ZOONOSES BACTERIAL PATHOGEN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 23(5), 762-769. SID. https://sid.ir/paper/81980/en

Vancouver: Copy

GHASEMI BEHZAD, Beyzaei Hamid, HASHEMI SEYED HADI, ASKARI VAHID REZA. STUDY ON ANTIBACTERIAL EFFECT OF NEW THIAZOLE AND IMIDAZOLE DERIVATIVES ON ZOONOSES BACTERIAL PATHOGEN. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;23(5):762-769. Available from: https://sid.ir/paper/81980/en

IEEE: Copy

BEHZAD GHASEMI, Hamid Beyzaei, SEYED HADI HASHEMI, and VAHID REZA ASKARI, “STUDY ON ANTIBACTERIAL EFFECT OF NEW THIAZOLE AND IMIDAZOLE DERIVATIVES ON ZOONOSES BACTERIAL PATHOGEN,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 5, pp. 762–769, 2017, [Online]. Available: https://sid.ir/paper/81980/en

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