The Effect of Eight Weeks of Moderate and High Intensity Resistance Training on Muscular miR-1, miR-206 Expression and Serum IGF-I in Wistar Older Rats

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SHANAZARI Z.; FARAMARZI M.; BANITALEBI E.; HEMMATI R.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2020 | Volume:12 | Issue:46 Page(s): 57-76

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Title

The Effect of Eight Weeks of Moderate and High Intensity Resistance Training on Muscular miR-1, miR-206 Expression and Serum IGF-I in Wistar Older Rats

Author(s)

SHANAZARI Z. | FARAMARZI M. | BANITALEBI E. | HEMMATI R. | Issue Writer Certificate

Keywords

miRQ1

1Q1

miRQ1

206Q1

IGFQ1

1Q1

SarcopeniaQ1

Abstract

One of the most important and prevalent consequences in elderly people is age-related muscular atrophy or Sarcopenia. Sarcopenia is associated with a significant reduction in muscle strength and mass. The purpose of this study was to investigate the effect of moderate and high intensity resistance training on miR-1, miR-206 expression and serum IGF-1 in elderly rats. 30 male Wistar rats (23 months old) were randomly divided into two experiment and one control group including moderate intensity resistance training (n = 9), high intensity resistance training (n = 8) and the control group (n =8. Resistance training included 8 weeks of climbing a ladder with high intensity (80% MVCC) and moderate intensity (60% of MVCC) and 5 days a week. After completing training, miR-1, miR-206 expression was measured using the by RT-PCR method in Soleus and FHL muscle and IGF-I in serum. The statistical analysis was performed using One Way ANOVA test with significance level of (P <0. 05). The results showed that in both resistance training group, miR-1 and miR-206 expression were significantly lower than those in control group and IGF-1 concentrations was significantly higher in both high and moderate resistance groups than control group (P <0. 05). High intensity resistance training was more effective for both miR-1 and miR-206 in FHL muscle and serumIGF-1. It seems that resistance training with moderate and high intensity can change the resting levels microRNAs related to muscular atrophy (miR-1, miR-206) and its target gene (IGF-1) in older rats and lead to the prevention of Sarcopenia in older peoples.

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APA: Copy

SHANAZARI, Z., FARAMARZI, M., BANITALEBI, E., & HEMMATI, R.. (2020). The Effect of Eight Weeks of Moderate and High Intensity Resistance Training on Muscular miR-1, miR-206 Expression and Serum IGF-I in Wistar Older Rats. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 12(46 ), 57-76. SID. https://sid.ir/paper/362778/en

Vancouver: Copy

SHANAZARI Z., FARAMARZI M., BANITALEBI E., HEMMATI R.. The Effect of Eight Weeks of Moderate and High Intensity Resistance Training on Muscular miR-1, miR-206 Expression and Serum IGF-I in Wistar Older Rats. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2020;12(46 ):57-76. Available from: https://sid.ir/paper/362778/en

IEEE: Copy

Z. SHANAZARI, M. FARAMARZI, E. BANITALEBI, and R. HEMMATI, “The Effect of Eight Weeks of Moderate and High Intensity Resistance Training on Muscular miR-1, miR-206 Expression and Serum IGF-I in Wistar Older Rats,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 12, no. 46 , pp. 57–76, 2020, [Online]. Available: https://sid.ir/paper/362778/en

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