The Effect of Different Intensities Endurance and Resistance Training on Expression Mir-133a and Two Transcription Factors of Osteogenic and Adipogenic, Runx2 and Pparγ on Bone Marrow in Old Male Wistar Rats

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Hemati Farsani z.; BANITALEBI E.; FARAMARZI M.; BIGHAM SADEGH A.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2019 | Volume:11 | Issue:42 Page(s): 61-78

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Title

The Effect of Different Intensities Endurance and Resistance Training on Expression Mir-133a and Two Transcription Factors of Osteogenic and Adipogenic, Runx2 and Pparγ on Bone Marrow in Old Male Wistar Rats

Author(s)

Hemati Farsani z. | BANITALEBI E. | FARAMARZI M. | BIGHAM SADEGH A. | Issue Writer Certificate

Keywords

Bone MetabolismQ1

Mir-133aQ1

Runx2Q1

Endurance and Resistance TrainingQ1

PPARγQ1

Abstract

Objective: aging is known as a low bone mass and microarchitectural deterioration of bone tissue, resulting in increased risk of fracture. However, appropriate exercise for the prevention and treatment of osteoporosis has not been determined. The aim of this study was to determine the effects of compare effects of aerobic and resistance exercise training protocols with different intensities on microRNA-133a (Mir-133a), Runx2 and Peroxisome proliferator-activated receptors-gamma (PPARγ ) in bone marrow Wistar elderly rats. This experimental study was done on 40 Wistar male rats (23-month-old and with an average weight of 441. 75 gram). They were randomly divided into five equal groups (n=8) include moderate (60% Maximum voluntary carrying capacity) or high (80% Maximum voluntary carrying capacity) intensity resistance training, moderate (60-110% Maximum speed) or high (80-110% Maximum speed) intensity endurance training and control. The two training groups completed 8 weeks of training program, 5 days a week according to resistance or endurance protocols. After completing training, expression of Mir-133a, Runx2 and PPARγ on bone marrow were measured RT-PCR. The statistical analysis was performed using Kruskal-Wallis test with significance level of P <0. 05. There was no significance in expression of Mir-133a (P=0. 197), Runx2 (P=0. 960) and PPARγ (P=0. 872) in five groups. However, the Runx2 expression level ratio to PPARγ was higher in the moderate training group. Also, the highest decrease of Mir-133a was observed in the resistance training group. Conclusion: Investigating cellular changes in bone after such exercises requires longer periods of exercise, or other measurements, especially at proteomics level, that should be investigated in future research.

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APA: Copy

Hemati Farsani, z., BANITALEBI, E., FARAMARZI, M., & BIGHAM SADEGH, A.. (2019). The Effect of Different Intensities Endurance and Resistance Training on Expression Mir-133a and Two Transcription Factors of Osteogenic and Adipogenic, Runx2 and Pparγ on Bone Marrow in Old Male Wistar Rats. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 11(42 ), 61-78. SID. https://sid.ir/paper/377604/en

Vancouver: Copy

Hemati Farsani z., BANITALEBI E., FARAMARZI M., BIGHAM SADEGH A.. The Effect of Different Intensities Endurance and Resistance Training on Expression Mir-133a and Two Transcription Factors of Osteogenic and Adipogenic, Runx2 and Pparγ on Bone Marrow in Old Male Wistar Rats. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2019;11(42 ):61-78. Available from: https://sid.ir/paper/377604/en

IEEE: Copy

z. Hemati Farsani, E. BANITALEBI, M. FARAMARZI, and A. BIGHAM SADEGH, “The Effect of Different Intensities Endurance and Resistance Training on Expression Mir-133a and Two Transcription Factors of Osteogenic and Adipogenic, Runx2 and Pparγ on Bone Marrow in Old Male Wistar Rats,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 11, no. 42 , pp. 61–78, 2019, [Online]. Available: https://sid.ir/paper/377604/en

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