Cytotoxicity and Apoptotic Effect of Chitosan Nanoparticles Containing Hydroalcoholic Extract of Physalis alkekengi on HT29 Cell Line

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MAHMOUDI REZA; Tajali Ardakani Maryam; BARDANIA HASSAN

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Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:29 | Issue:180 Page(s): 102-107

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Title

Cytotoxicity and Apoptotic Effect of Chitosan Nanoparticles Containing Hydroalcoholic Extract of Physalis alkekengi on HT29 Cell Line

Author(s)

MAHMOUDI REZA | Tajali Ardakani Maryam | BARDANIA HASSAN | Issue Writer Certificate

Keywords

chitosan nanoparticlesQ1

apoptosis assayQ1

anticancer activityQ1

hydro-alcoholic extractQ2

Physalis alkekengiQ1

Abstract

Background and purpose: In this study, we aimed to evaluate the anticancer activity of Physalis alkekengi extract encapsulated into chitosan nanoparticles on HT29 cell line. Materials and methods: The fruits of the P. alkekengi were collected from Kohgiluyeh Boyerahmad province in south-west of Iran and dried in a dark environment. Then, the hydroalcoholic extract of the plant was extracted by percolation and encapsulated into chitosan nanoparticles. The toxicity effect of three samples; chitosan alone, chitosan containing the extract and the extract of P. alkekengi was investigated using MTT assay. Finally, Annxin V/propidium iodide (PI) kit was used to study the apoptotic effect of samples. Results: According to the MTT assay, during 72 hours, the cytotoxicity effect of chitosan nanoparticles of 160 nm containing the extract increased significantly (P< 0. 05). Moreover, the apoptosis assay indicated that chitosan nanoparticles containing the extract had more apoptotic effects than the extract alone (71% vs. 43%). Conclusion: P. alkekengi extract encapsulated into chitosan nanoparticles had more anticancer activity compared with that of the extract alone.

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APA: Copy

MAHMOUDI, REZA, Tajali Ardakani, Maryam, & BARDANIA, HASSAN. (2020). Cytotoxicity and Apoptotic Effect of Chitosan Nanoparticles Containing Hydroalcoholic Extract of Physalis alkekengi on HT29 Cell Line. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(180 ), 102-107. SID. https://sid.ir/paper/362867/en

Vancouver: Copy

MAHMOUDI REZA, Tajali Ardakani Maryam, BARDANIA HASSAN. Cytotoxicity and Apoptotic Effect of Chitosan Nanoparticles Containing Hydroalcoholic Extract of Physalis alkekengi on HT29 Cell Line. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;29(180 ):102-107. Available from: https://sid.ir/paper/362867/en

IEEE: Copy

REZA MAHMOUDI, Maryam Tajali Ardakani, and HASSAN BARDANIA, “Cytotoxicity and Apoptotic Effect of Chitosan Nanoparticles Containing Hydroalcoholic Extract of Physalis alkekengi on HT29 Cell Line,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 180 , pp. 102–107, 2020, [Online]. Available: https://sid.ir/paper/362867/en

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